{"id":12076,"date":"2015-12-26T10:04:00","date_gmt":"2015-12-26T10:04:00","guid":{"rendered":"https:\/\/genomecanada.ca\/drupal\/news_release\/sickkids-researchers-make-great-strides-towards-cracking-autism-code-2\/"},"modified":"2015-12-26T10:04:00","modified_gmt":"2015-12-26T10:04:00","slug":"sickkids-researchers-make-great-strides-towards-cracking-autism-code-2","status":"publish","type":"post","link":"https:\/\/genomecanada.ca\/fr\/sickkids-researchers-make-great-strides-towards-cracking-autism-code-2\/","title":{"rendered":"SickKids researchers make great strides towards cracking the autism code"},"content":{"rendered":"

Recent advances in genome sequencing technology havefacilitated rapid identification of genetic alterations in genes associated withAutism Spectrum Disorder (ASD). The universal challenge in the field ofgenetics has been to determine whether these mutations will result in autism.<\/p>\n

In a study to be published in the May 25th advanced online edition NatureGenetics, researchers at The Hospital for Sick Children (SickKids) andUniversity of Toronto have essentially unraveled the autism code, by creating a\u201cgenetic formula\u201d that will enable clinicians to identify genetic mutations thathave the highest and lowest likelihood of causing ASD.<\/p>\n

ASD, which has recently been reported to affect one in every 68 children, is aneurodevelopmental disorder characterized by impairments in socialinteraction and communication, as well as repetitive and restrictive behaviors.It is well established that genetics has a major role in the development ofautism, which in itself represents a collection of clinically similar disorders.<\/p>\n

\u201cThere has been incredible progress finding genetic answers, but these areoften accompanied by puzzling clinical observations. Previous research hasrevealed many conundrums such as mutation carriers who do not exhibitsymptoms of autism,\u201d says Dr. Stephen Scherer, principal author of the studyand senior scientist and director of The Centre for Applied Genomics atSickKids and the University of Toronto McLaughlin Centre. \u201cIn our new studywe\u2019ve finally discovered a unifying set of characteristics in the DNA that we canweave into a \u2018genetic formula\u2019 that helps us calculate which genetic mutationshave the highest probability of causing autism, and equally important, whichalterations do not have a role.\u201d<\/p>\n

Dr. Mohammed Uddin, a postdoctoral fellow on Scherer\u2019s team determinedthat the key to solving the enigma of the autism mutation code, resides inrecognizing small segments (called exons) of genes that are both \u201chighlyconserved\u201d in human evolution and \u201cturned on\u201d  during early braindevelopment.<\/p>\n

\u201cThe timing of this gene activation is an important finding. The fact that thesegenes could be turned on prenatally, gives us a clue as to when autism couldstart to develop,\u201d says Scherer.<\/p>\n

Metaphorically, genes are often compared to an orchestra, with the mostimportant exons representing instruments like the violin that crescendo (turnon, or express) at critical times in the developmental symphony.<\/p>\n

The Toronto team identified almost four thousand such brain exons in morethan seventeen hundred different genes. In addition, the one hundred or soknown autism susceptibility genes already used for diagnostic testing werefurther validated by the new approach, as were genes involved in otherneurodevelopmental conditions such as intellectual disability, which is often afeature of ASD.<\/p>\n

Scherer predicts that  many of the novel genes discovered by his group thatbear these newly defined unique characteristics, will eventually be proven byother means to be involved in autism or intellectual disability, or other relatedmedical conditions associated with brain development or cognition.<\/p>\n

\u201cThis groundbreaking work will have immediate impact on efforts to developmore accurate genetic diagnostic tests aimed at improving earlier detectionand clinical decisions to begin intervention\u201d says Dr. Robert Ring, ChiefScientific Officer of Autism Speaks. \u201cImprovements in our understanding ofmechanisms involved in brain expression of disease mutations will also helpto reveal new biological space worth targeting for the development ofmedicines that benefit individuals with autism and related neurodevelopmentaldisorders.\u201d<\/p>\n

This research was supported by grants from the University of TorontoMcLaughlin Centre, NeuroDevNet, Genome Canada and the OntarioGenomics Institute, the Canadian Institutes for Health Research (CIHR), theCanadian Institute for Advanced Research, the Canada Foundation forInnovation, the government of Ontario, the Ontario Brain Institute, AutismSpeaks and SickKids Foundation.<\/p>\n

This research has been developed in close collaboration with the IndustryPartnerships and Commercialization Office at SickKids. The technologymentioned above is available for licensing.<\/p>\n

About The Hospital for Sick Children<\/p>\n

The Hospital for Sick Children (SickKids) is recognized as one of the world\u2019sforemost paediatric health-care institutions and is Canada\u2019s leading centrededicated to advancing children\u2019s health through the integration of patient care,research and education. Founded in 1875 and affiliated with the University ofToronto, SickKids is one of Canada\u2019s most research- intensive hospitals andhas generated discoveries that have helped children globally.  Its mission is toprovide the best in complex and specialized family-centred care; pioneerscientific and clinical advancements; share expertise; foster an academicenvironment that nurtures health-care professionals; and champion anaccessible, comprehensive and sustainable child health system. SickKids is proud of its vision for Healthier Children. A Better World. For more information,please visit www.sickkids.ca<\/p>\n

For more information, please contact:<\/p>\n

Caitlin McNamee-Lamb<\/p>\n

The Hospital for Sick Children<\/p>\n

416-813-7654, ext. 201436<\/p>\n

caitlin.mcnamee-lamb@sickkids.ca<\/p>\n

Matet Nebres<\/p>\n

The Hospital for Sick Children<\/p>\n

416-813-6380<\/p>\n

matet.nebres@sickkids.ca<\/p>\n","protected":false},"excerpt":{"rendered":"

Recent advances in genome sequencing technology havefacilitated rapid identification of genetic alterations in genes associated withAutism Spectrum Disorder (ASD). The universal challenge in the field ofgenetics has been to determine whether these mutations will result in autism. In a study to be published in the May 25th advanced online edition NatureGenetics, researchers at The Hospital for Sick Children (SickKids) andUniversity of Toronto have essentially unraveled the autism code, by creating a\u201cgenetic formula\u201d that will enable clinicians to identify genetic mutations thathave the highest and lowest likelihood of causing ASD. ASD, which has recently been reported to affect one in every 68 children, is aneurodevelopmental disorder characterized by impairments in socialinteraction and communication, as well as repetitive and restrictive behaviors.It is well established that genetics has a major role in the development ofautism, which in itself represents a collection of clinically similar disorders. \u201cThere has been incredible progress finding genetic answers, but these areoften accompanied by puzzling clinical observations. Previous research hasrevealed many conundrums such as mutation carriers who do not exhibitsymptoms of autism,\u201d says Dr. Stephen Scherer, principal author of the studyand senior scientist and director of The Centre for Applied Genomics atSickKids and the University of Toronto McLaughlin Centre. \u201cIn our new studywe\u2019ve finally discovered a unifying set of characteristics in the DNA that we canweave into a \u2018genetic formula\u2019 that helps us calculate which genetic mutationshave the highest probability of causing autism, and equally important, whichalterations do not have a role.\u201d Dr. Mohammed Uddin, a postdoctoral fellow on Scherer\u2019s team determinedthat the key to solving the enigma of the autism mutation code, resides inrecognizing small segments (called exons) of genes that are both \u201chighlyconserved\u201d in human evolution and \u201cturned on\u201d  during early braindevelopment. \u201cThe timing of this gene activation is an important finding. The fact that thesegenes could be turned on prenatally, gives us a clue as to when autism couldstart to develop,\u201d says Scherer. Metaphorically, genes are often compared to an orchestra, with the mostimportant exons representing instruments like the violin that crescendo (turnon, or express) at critical times in the developmental symphony. The Toronto team identified almost four thousand such brain exons in morethan seventeen hundred different genes. In addition, the one hundred or soknown autism susceptibility genes already used for diagnostic testing werefurther validated by the new approach, as were genes involved in otherneurodevelopmental conditions such as intellectual disability, which is often afeature of ASD. Scherer predicts that  many of the novel genes discovered by his group thatbear these newly defined unique characteristics, will eventually be proven byother means to be involved in autism or intellectual disability, or other relatedmedical conditions associated with brain development or cognition. \u201cThis groundbreaking work will have immediate impact on efforts to developmore accurate genetic diagnostic tests aimed at improving earlier detectionand clinical decisions to begin intervention\u201d says Dr. Robert Ring, ChiefScientific Officer of Autism Speaks. \u201cImprovements in our understanding ofmechanisms involved in brain expression of disease mutations will also helpto reveal new biological space worth targeting for the development ofmedicines that benefit individuals with autism and related neurodevelopmentaldisorders.\u201d This research was supported by grants from the University of TorontoMcLaughlin Centre, NeuroDevNet, Genome Canada and the OntarioGenomics Institute, the Canadian Institutes for Health Research (CIHR), theCanadian Institute for Advanced Research, the Canada Foundation forInnovation, the government of Ontario, the Ontario Brain Institute, AutismSpeaks and SickKids Foundation. This research has been developed in close collaboration with the IndustryPartnerships and Commercialization Office at SickKids. The technologymentioned above is available for licensing. About The Hospital for Sick Children The Hospital for Sick Children (SickKids) is recognized as one of the world\u2019sforemost paediatric health-care institutions and is Canada\u2019s leading centrededicated to advancing children\u2019s health through the integration of patient care,research and education. Founded in 1875 and affiliated with the University ofToronto, SickKids is one of Canada\u2019s most research- intensive hospitals andhas generated discoveries that have helped children globally.  Its mission is toprovide the best in complex and specialized family-centred care; pioneerscientific and clinical advancements; share expertise; foster an academicenvironment that nurtures health-care professionals; and champion anaccessible, comprehensive and sustainable child health system. SickKids is proud of its vision for Healthier Children. A Better World. For more information,please visit www.sickkids.ca For more information, please contact: Caitlin McNamee-Lamb […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[127],"tags":[],"mission-categories":[],"class_list":["post-12076","post","type-post","status-publish","format-standard","hentry","category-news-fr"],"acf":[],"yoast_head":"\nSickKids researchers make great strides towards cracking the autism code - GenomeCanada<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/genomecanada.ca\/fr\/sickkids-researchers-make-great-strides-towards-cracking-autism-code-2\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"SickKids researchers make great strides towards cracking the autism code - GenomeCanada\" \/>\n<meta property=\"og:description\" content=\"Recent advances in genome sequencing technology havefacilitated rapid identification of genetic alterations in genes associated withAutism Spectrum Disorder (ASD). The universal challenge in the field ofgenetics has been to determine whether these mutations will result in autism. In a study to be published in the May 25th advanced online edition NatureGenetics, researchers at The Hospital for Sick Children (SickKids) andUniversity of Toronto have essentially unraveled the autism code, by creating a\u201cgenetic formula\u201d that will enable clinicians to identify genetic mutations thathave the highest and lowest likelihood of causing ASD. ASD, which has recently been reported to affect one in every 68 children, is aneurodevelopmental disorder characterized by impairments in socialinteraction and communication, as well as repetitive and restrictive behaviors.It is well established that genetics has a major role in the development ofautism, which in itself represents a collection of clinically similar disorders. \u201cThere has been incredible progress finding genetic answers, but these areoften accompanied by puzzling clinical observations. Previous research hasrevealed many conundrums such as mutation carriers who do not exhibitsymptoms of autism,\u201d says Dr. Stephen Scherer, principal author of the studyand senior scientist and director of The Centre for Applied Genomics atSickKids and the University of Toronto McLaughlin Centre. \u201cIn our new studywe\u2019ve finally discovered a unifying set of characteristics in the DNA that we canweave into a \u2018genetic formula\u2019 that helps us calculate which genetic mutationshave the highest probability of causing autism, and equally important, whichalterations do not have a role.\u201d Dr. Mohammed Uddin, a postdoctoral fellow on Scherer\u2019s team determinedthat the key to solving the enigma of the autism mutation code, resides inrecognizing small segments (called exons) of genes that are both \u201chighlyconserved\u201d in human evolution and \u201cturned on\u201d  during early braindevelopment. \u201cThe timing of this gene activation is an important finding. The fact that thesegenes could be turned on prenatally, gives us a clue as to when autism couldstart to develop,\u201d says Scherer. Metaphorically, genes are often compared to an orchestra, with the mostimportant exons representing instruments like the violin that crescendo (turnon, or express) at critical times in the developmental symphony. The Toronto team identified almost four thousand such brain exons in morethan seventeen hundred different genes. In addition, the one hundred or soknown autism susceptibility genes already used for diagnostic testing werefurther validated by the new approach, as were genes involved in otherneurodevelopmental conditions such as intellectual disability, which is often afeature of ASD. Scherer predicts that  many of the novel genes discovered by his group thatbear these newly defined unique characteristics, will eventually be proven byother means to be involved in autism or intellectual disability, or other relatedmedical conditions associated with brain development or cognition. \u201cThis groundbreaking work will have immediate impact on efforts to developmore accurate genetic diagnostic tests aimed at improving earlier detectionand clinical decisions to begin intervention\u201d says Dr. Robert Ring, ChiefScientific Officer of Autism Speaks. \u201cImprovements in our understanding ofmechanisms involved in brain expression of disease mutations will also helpto reveal new biological space worth targeting for the development ofmedicines that benefit individuals with autism and related neurodevelopmentaldisorders.\u201d This research was supported by grants from the University of TorontoMcLaughlin Centre, NeuroDevNet, Genome Canada and the OntarioGenomics Institute, the Canadian Institutes for Health Research (CIHR), theCanadian Institute for Advanced Research, the Canada Foundation forInnovation, the government of Ontario, the Ontario Brain Institute, AutismSpeaks and SickKids Foundation. This research has been developed in close collaboration with the IndustryPartnerships and Commercialization Office at SickKids. The technologymentioned above is available for licensing. About The Hospital for Sick Children The Hospital for Sick Children (SickKids) is recognized as one of the world\u2019sforemost paediatric health-care institutions and is Canada\u2019s leading centrededicated to advancing children\u2019s health through the integration of patient care,research and education. Founded in 1875 and affiliated with the University ofToronto, SickKids is one of Canada\u2019s most research- intensive hospitals andhas generated discoveries that have helped children globally.  Its mission is toprovide the best in complex and specialized family-centred care; pioneerscientific and clinical advancements; share expertise; foster an academicenvironment that nurtures health-care professionals; and champion anaccessible, comprehensive and sustainable child health system. SickKids is proud of its vision for Healthier Children. A Better World. For more information,please visit www.sickkids.ca For more information, please contact: Caitlin McNamee-Lamb […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/genomecanada.ca\/fr\/sickkids-researchers-make-great-strides-towards-cracking-autism-code-2\/\" \/>\n<meta property=\"og:site_name\" content=\"GenomeCanada\" \/>\n<meta property=\"article:published_time\" content=\"2015-12-26T10:04:00+00:00\" \/>\n<meta name=\"author\" content=\"Pierre\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"Pierre\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"7 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/sickkids-researchers-make-great-strides-towards-cracking-autism-code-2\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/sickkids-researchers-make-great-strides-towards-cracking-autism-code-2\\\/\"},\"author\":{\"name\":\"Pierre\",\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/#\\\/schema\\\/person\\\/9178d2ca6aca04c78924c5863c96697a\"},\"headline\":\"SickKids researchers make great strides towards cracking the autism code\",\"datePublished\":\"2015-12-26T10:04:00+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/sickkids-researchers-make-great-strides-towards-cracking-autism-code-2\\\/\"},\"wordCount\":1407,\"publisher\":{\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/#organization\"},\"articleSection\":[\"News\"],\"inLanguage\":\"fr-FR\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/sickkids-researchers-make-great-strides-towards-cracking-autism-code-2\\\/\",\"url\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/sickkids-researchers-make-great-strides-towards-cracking-autism-code-2\\\/\",\"name\":\"SickKids researchers make great strides towards cracking the autism code - 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GenomeCanada","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/genomecanada.ca\/fr\/sickkids-researchers-make-great-strides-towards-cracking-autism-code-2\/","og_locale":"fr_FR","og_type":"article","og_title":"SickKids researchers make great strides towards cracking the autism code - GenomeCanada","og_description":"Recent advances in genome sequencing technology havefacilitated rapid identification of genetic alterations in genes associated withAutism Spectrum Disorder (ASD). The universal challenge in the field ofgenetics has been to determine whether these mutations will result in autism. In a study to be published in the May 25th advanced online edition NatureGenetics, researchers at The Hospital for Sick Children (SickKids) andUniversity of Toronto have essentially unraveled the autism code, by creating a\u201cgenetic formula\u201d that will enable clinicians to identify genetic mutations thathave the highest and lowest likelihood of causing ASD. ASD, which has recently been reported to affect one in every 68 children, is aneurodevelopmental disorder characterized by impairments in socialinteraction and communication, as well as repetitive and restrictive behaviors.It is well established that genetics has a major role in the development ofautism, which in itself represents a collection of clinically similar disorders. \u201cThere has been incredible progress finding genetic answers, but these areoften accompanied by puzzling clinical observations. Previous research hasrevealed many conundrums such as mutation carriers who do not exhibitsymptoms of autism,\u201d says Dr. Stephen Scherer, principal author of the studyand senior scientist and director of The Centre for Applied Genomics atSickKids and the University of Toronto McLaughlin Centre. \u201cIn our new studywe\u2019ve finally discovered a unifying set of characteristics in the DNA that we canweave into a \u2018genetic formula\u2019 that helps us calculate which genetic mutationshave the highest probability of causing autism, and equally important, whichalterations do not have a role.\u201d Dr. Mohammed Uddin, a postdoctoral fellow on Scherer\u2019s team determinedthat the key to solving the enigma of the autism mutation code, resides inrecognizing small segments (called exons) of genes that are both \u201chighlyconserved\u201d in human evolution and \u201cturned on\u201d  during early braindevelopment. \u201cThe timing of this gene activation is an important finding. The fact that thesegenes could be turned on prenatally, gives us a clue as to when autism couldstart to develop,\u201d says Scherer. Metaphorically, genes are often compared to an orchestra, with the mostimportant exons representing instruments like the violin that crescendo (turnon, or express) at critical times in the developmental symphony. The Toronto team identified almost four thousand such brain exons in morethan seventeen hundred different genes. In addition, the one hundred or soknown autism susceptibility genes already used for diagnostic testing werefurther validated by the new approach, as were genes involved in otherneurodevelopmental conditions such as intellectual disability, which is often afeature of ASD. Scherer predicts that  many of the novel genes discovered by his group thatbear these newly defined unique characteristics, will eventually be proven byother means to be involved in autism or intellectual disability, or other relatedmedical conditions associated with brain development or cognition. \u201cThis groundbreaking work will have immediate impact on efforts to developmore accurate genetic diagnostic tests aimed at improving earlier detectionand clinical decisions to begin intervention\u201d says Dr. Robert Ring, ChiefScientific Officer of Autism Speaks. \u201cImprovements in our understanding ofmechanisms involved in brain expression of disease mutations will also helpto reveal new biological space worth targeting for the development ofmedicines that benefit individuals with autism and related neurodevelopmentaldisorders.\u201d This research was supported by grants from the University of TorontoMcLaughlin Centre, NeuroDevNet, Genome Canada and the OntarioGenomics Institute, the Canadian Institutes for Health Research (CIHR), theCanadian Institute for Advanced Research, the Canada Foundation forInnovation, the government of Ontario, the Ontario Brain Institute, AutismSpeaks and SickKids Foundation. This research has been developed in close collaboration with the IndustryPartnerships and Commercialization Office at SickKids. The technologymentioned above is available for licensing. About The Hospital for Sick Children The Hospital for Sick Children (SickKids) is recognized as one of the world\u2019sforemost paediatric health-care institutions and is Canada\u2019s leading centrededicated to advancing children\u2019s health through the integration of patient care,research and education. Founded in 1875 and affiliated with the University ofToronto, SickKids is one of Canada\u2019s most research- intensive hospitals andhas generated discoveries that have helped children globally.  Its mission is toprovide the best in complex and specialized family-centred care; pioneerscientific and clinical advancements; share expertise; foster an academicenvironment that nurtures health-care professionals; and champion anaccessible, comprehensive and sustainable child health system. SickKids is proud of its vision for Healthier Children. A Better World. For more information,please visit www.sickkids.ca For more information, please contact: Caitlin McNamee-Lamb […]","og_url":"https:\/\/genomecanada.ca\/fr\/sickkids-researchers-make-great-strides-towards-cracking-autism-code-2\/","og_site_name":"GenomeCanada","article_published_time":"2015-12-26T10:04:00+00:00","author":"Pierre","twitter_card":"summary_large_image","twitter_misc":{"\u00c9crit par":"Pierre","Dur\u00e9e de lecture estim\u00e9e":"7 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/genomecanada.ca\/fr\/sickkids-researchers-make-great-strides-towards-cracking-autism-code-2\/#article","isPartOf":{"@id":"https:\/\/genomecanada.ca\/fr\/sickkids-researchers-make-great-strides-towards-cracking-autism-code-2\/"},"author":{"name":"Pierre","@id":"https:\/\/genomecanada.ca\/fr\/#\/schema\/person\/9178d2ca6aca04c78924c5863c96697a"},"headline":"SickKids researchers make great strides towards cracking the autism code","datePublished":"2015-12-26T10:04:00+00:00","mainEntityOfPage":{"@id":"https:\/\/genomecanada.ca\/fr\/sickkids-researchers-make-great-strides-towards-cracking-autism-code-2\/"},"wordCount":1407,"publisher":{"@id":"https:\/\/genomecanada.ca\/fr\/#organization"},"articleSection":["News"],"inLanguage":"fr-FR"},{"@type":"WebPage","@id":"https:\/\/genomecanada.ca\/fr\/sickkids-researchers-make-great-strides-towards-cracking-autism-code-2\/","url":"https:\/\/genomecanada.ca\/fr\/sickkids-researchers-make-great-strides-towards-cracking-autism-code-2\/","name":"SickKids researchers make great strides towards cracking the autism code - 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