{"id":12211,"date":"2019-01-15T17:54:30","date_gmt":"2019-01-15T17:54:30","guid":{"rendered":"https:\/\/genomecanada.ca\/drupal\/news_release\/cancer-du-sein-des-chercheurs-mettent-au-point-le-modele-de-prediction-du-risque-le-plus\/"},"modified":"2019-01-15T17:54:30","modified_gmt":"2019-01-15T17:54:30","slug":"cancer-du-sein-des-chercheurs-mettent-au-point-le-modele-de-prediction-du-risque-le-plus","status":"publish","type":"post","link":"https:\/\/genomecanada.ca\/fr\/cancer-du-sein-des-chercheurs-mettent-au-point-le-modele-de-prediction-du-risque-le-plus\/","title":{"rendered":"Cancer du sein – Des chercheurs mettent au point le mod\u00e8le de pr\u00e9diction du risque le plus pr\u00e9cis \u00e0 ce jour"},"content":{"rendered":"

Un simple test de salive pourrait permettre d’estimer avec une pr\u00e9cision in\u00e9gal\u00e9e le risque qu’une femme ait un cancer du sein au cours de sa vie, selon une \u00e9tude internationale publi\u00e9e aujourd’hui \u00e0 laquelle ont particip\u00e9 des chercheurs de l’Universit\u00e9 Laval et du Centre de recherche du CHU de Qu\u00e9bec-Universit\u00e9 Laval. En combinant le profil g\u00e9n\u00e9tique obtenu gr\u00e2ce \u00e0 un test de salive \u00e0 un mod\u00e8le statistique qui tient compte des ant\u00e9c\u00e9dents familiaux, des facteurs hormonaux et des habitudes de vie, les chercheurs sont parvenus \u00e0 estimer le risque global de cancer du sein couru par chaque femme, ouvrant la porte \u00e0 la personnalisation des protocoles de d\u00e9pistage de cette maladie.<\/p>\n

\u00ab\u2009Plusieurs centaines de chercheurs \u00e0 travers le monde ont mis en commun les \u00e9chantillons d’ADN r\u00e9colt\u00e9s dans leurs projets respectifs et men\u00e9 une analyse g\u00e9nomique sur 94\u2009000 femmes qui avaient eu un cancer du sein et sur un groupe t\u00e9moin de 75\u2009000 femmes\u2009\u00bb, explique l’un des responsables de l’\u00e9tude, le professeur Jacques Simard, titulaire de la chaire de recherche du Canada en oncog\u00e9n\u00e9tique \u00e0 la Facult\u00e9 de m\u00e9decine de l’Universit\u00e9 Laval et chercheur au Centre de recherche du CHU de Qu\u00e9bec-Universit\u00e9 Laval. Gr\u00e2ce \u00e0 des analyses statistiques sophistiqu\u00e9es, nous avons mis au point un score de risque de cancer du sein qui inclut 313 variations g\u00e9n\u00e9tiques et l’avons ensuite valid\u00e9 sur pr\u00e8s de 220\u2009000 femmes.\u2009\u00bb<\/p>\n

Au Qu\u00e9bec et au Canada, le d\u00e9pistage du cancer du sein se fait essentiellement par mammographie et vise g\u00e9n\u00e9ralement les femmes de 50 \u00e0 69 ans. Or, malgr\u00e9 ces pr\u00e9cautions, bon nombre de femmes \u00e0 haut risque de d\u00e9velopper la maladie \u00e9chappent au d\u00e9pistage pr\u00e9ventif. Le mod\u00e8le mis au point par le professeur Simard et ses coll\u00e8gues pourra aider \u00e0 personnaliser le d\u00e9pistage du cancer du sein en fonction du risque individuel. \u00ab\u2009Gr\u00e2ce aux pr\u00e9dictions de notre mod\u00e8le, il sera possible d’\u00e9tablir un risque individuel pour chaque femme et de lui proposer une approche de d\u00e9pistage personnalis\u00e9e, peu importe l’\u00e2ge, explique le chercheur. Il lui suffira de fournir un \u00e9chantillon de salive \u00e0 une seule reprise au cours de sa vie lorsqu’elle aura atteint, par exemple, le d\u00e9but de la quarantaine.\u2009\u00bb<\/p>\n

\u00c0 quand l’int\u00e9gration de ce mod\u00e8le dans notre syst\u00e8me de soins de sant\u00e9?<\/strong>
\nUne \u00e9quipe dirig\u00e9e par Jacques Simard travaille actuellement \u00e0 un projet de pr\u00e9implantation de ce mod\u00e8le aupr\u00e8s de 10\u2009000 femmes au Qu\u00e9bec et en Ontario. <\/p>\n

\u00ab\u2009Notre but est d’\u00e9valuer l’acceptabilit\u00e9, la faisabilit\u00e9 et l’efficacit\u00e9 d’une approche de d\u00e9pistage fond\u00e9e sur le risque. Nous \u00e9tudierons aussi les enjeux organisationnels de l’implantation d’un d\u00e9pistage personnalis\u00e9 dans notre syst\u00e8me de sant\u00e9, de m\u00eame que les co\u00fbts et les b\u00e9n\u00e9fices qui en d\u00e9couleraient\u2009\u00bb, explique le scientifique.<\/p>\n

Ce projet d’int\u00e9gration et d’implantation est financ\u00e9 par G\u00e9nome Qu\u00e9bec, G\u00e9nome Canada, les Instituts de recherche en sant\u00e9 du Canada, la Fondation du cancer du sein du Qu\u00e9bec, le Ontario Research Fund et d’autres partenaires \u00e0 hauteur de 15,2 millions de dollars. Plus de d\u00e9tails sur les chercheurs impliqu\u00e9s dans ce projet interdisciplinaire et international<\/a> sont disponibles sur le site de G\u00e9nome Qu\u00e9bec.<\/p>\n

Les d\u00e9tails de cette perc\u00e9e sont pr\u00e9sent\u00e9s dans un article paru aujourd’hui dans la revue Genetics in Medicine<\/a> <\/em>et un autre article publi\u00e9 r\u00e9cemment dans The American Journal of Human Genetics.<\/a><\/em><\/p>\n

\u00c0 propos de G\u00e9nome Qu\u00e9bec : www.genomequebec.com<\/a> 
\n\u00c0 propos de l’Universit\u00e9 Laval : www.ulaval.ca<\/a> 
\n\u00c0 propos du Centre de recherche du CHU de Qu\u00e9bec-Universit\u00e9 Laval : www.crchudequebec.ulaval.ca<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Un simple test de salive pourrait permettre d’estimer avec une pr\u00e9cision in\u00e9gal\u00e9e le risque qu’une femme ait un cancer du sein au cours de sa vie, selon une \u00e9tude internationale publi\u00e9e aujourd’hui \u00e0 laquelle ont particip\u00e9 des chercheurs de l’Universit\u00e9 Laval et du Centre de recherche du CHU de Qu\u00e9bec-Universit\u00e9 Laval. En combinant le profil g\u00e9n\u00e9tique obtenu gr\u00e2ce […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[127],"tags":[],"mission-categories":[],"class_list":["post-12211","post","type-post","status-publish","format-standard","hentry","category-news-fr"],"acf":[],"yoast_head":"\nCancer du sein - Des chercheurs mettent au point le mod\u00e8le de pr\u00e9diction du risque le plus pr\u00e9cis \u00e0 ce jour - GenomeCanada<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/genomecanada.ca\/fr\/cancer-du-sein-des-chercheurs-mettent-au-point-le-modele-de-prediction-du-risque-le-plus\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cancer du sein - Des chercheurs mettent au point le mod\u00e8le de pr\u00e9diction du risque le plus pr\u00e9cis \u00e0 ce jour - GenomeCanada\" \/>\n<meta property=\"og:description\" content=\"Un simple test de salive pourrait permettre d’estimer avec une pr\u00e9cision in\u00e9gal\u00e9e le risque qu’une femme ait un cancer du sein au cours de sa vie, selon une \u00e9tude internationale publi\u00e9e aujourd’hui \u00e0 laquelle ont particip\u00e9 des chercheurs de l’Universit\u00e9 Laval et du Centre de recherche du CHU de Qu\u00e9bec-Universit\u00e9 Laval. 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