Hundreds of researchers from North America, Europe, Australia and Asia have joined together in a consortium to identify the genetic basis of the five most common forms of cancer \u2013 breast, prostate, lung, ovarian and colorectal. The group, called the OncoArray Consortium, developed a new customized genotyping tool \u2013 the OncoArray \u2013 manufactured by the U.S. genomics firm Illumina, Inc.<\/p>\n
\u00ab\u00a0The U.S. National Cancer Institute (NCI)-funded Genetic Associations and Mechanisms of Oncology (GAME-ON) initiative has been instrumental in bringing together multiple consortia and provides primary funding for the OncoArray Consortium. It allowed us to design a custom array that incorporates some 530,000 markers, which is planned for genotyping on over 425,000 samples from patients with one of the five types of cancer and control subjects from around the world. The sheer size of the sample is unprecedented for a study on the genetic factors involved in cancer. The OncoArray Consortium\u2019s work will provide insight into the inherited genetic basis of cancer and help scientists understand the underlying biology of cancer,\u00a0\u00bb explained Professor Christopher Amos, Head of Dartmouth\u2019s Center for Genomic Medicine, in the US, and the leader of the Lung Cancer consortium.<\/p>\n
This project is a direct extension of the work that has been achieved in recent years through the Collaborative Oncological Gene-Environment Study (COGS). \u00ab\u00a0The OncoArray will allow us to enhance our current understanding of the genetic factors associated with the risk of multiple cancers,\u00a0\u00bb explained Cancer Research UK funded Professor Douglas Easton of University of Cambridge (United Kingdom). \u00ab\u00a0We are proud to be involved in this international initiative, which will significantly accelerate the pace of discovery and lead to a greater understanding of a disease that affects one in three people,\u00a0\u00bb he continued.<\/p>\n
About 200 studies are involved in this project and nearly 50 countries participate in the consortium.<\/p>\n
Breast cancer samples will represent more than one-third of the samples under analysis. \u00ab\u00a0This is the largest number of samples ever used for research into the genetic basis of breast cancer risk,\u00a0\u00bb noted Universit\u00e9 Laval Professor Jacques Simard, who works at the Genomics Centre of the CHU de Qu\u00e9bec Research Centre, and chair holder of the Canada Research Chair in Oncogenetics. Qu\u00e9bec is at the forefront of this study, since the results will be used for a Qu\u00e9bec-based project aiming to improve the early detection of breast cancer, an initiative funded by G\u00e9nome Qu\u00e9bec, Genome Canada, the CIHR and the Qu\u00e9bec Breast Cancer Foundation. \u00ab\u00a0The work of Professor Jacques Simard will broaden our current understanding of this terrible disease, leading to better risk stratification tools that will increase our ability to deliver better-targeted screening services to those women at higher risk,\u00a0\u00bb said Marc LePage, President and CEO of G\u00e9nome Qu\u00e9bec.<\/p>\n
Leading efforts in prostate cancer are Brian Henderson and Ros Eeles. \u00ab\u00a0The OncoArray will provide fresh clues to the origin of these cancers and will hasten novel approaches to prevention and treatment,\u00a0\u00bb Dr. Henderson said. \u00ab\u00a0Every year 220,000 men in the US are diagnosed with prostate cancer, and there are 30,000 deaths. This indicates many people are being treated who don\u2019t need it. We hope this product will help us focus on the men who have the highest risk to the more fatal forms of this disease.\u00a0\u00bb<\/p>\n
\u00ab\u00a0This new research consortium will give us a fantastic opportunity to look at huge numbers of gene variants in prostate cancer patients across the world, helping expand our knowledge of the genetic basis of this disease,\u00a0\u00bb said Ros Eeles, Professor of Oncogenetics at The Institute of Cancer Research, London, which along with the University of Cambridge.<\/p>\n
Leading efforts in colorectal cancer is Kenneth T. Norris Jr. Chair in Cancer Prevention, Keck Medicine of USC, and Stephen Gruber, director, USC Norris Comprehensive Cancer Center, Keck Medicine of USC. Leading efforts in breast cancer on behalf of the US NCI are David J. Hunter, Dean for Academic Affairs, Harvard School of Public Health; for ovarian cancer the US NCI leader is Tom Sellers, Director of the Moffit Cancer Center in Florida. In addition, the Consortium of Investigators of Modifiers of BRCA1\/2, led by Georgia Chenevix-Trench, will genotype the OncoArray on about 30,000 women and men who carry mutations in theBRCA1 or BRCA2 genes.<\/p>\n
The project is funded through major grants from the U.S. National Cancer Institute to the GAME-ON initiative and the Division of Cancer Epidemiology and Genetics; Genome Canada\/G\u00e9nome Qu\u00e9bec\/CIHR\/Qu\u00e9bec Breast Cancer Foundation through the Personalized Risk Stratification for Prevention and Early Detection of Breast Cancer; Cancer Research UK (Cambridge University and The Institute of Cancer Research); Movember and Prostate Cancer UK (The Institute of Cancer Research) and EU\u2019s FP7 grant program (COGS), together with many other partners.<\/p>\n
About OncoArray Consortium<\/p>\n
Visit the Website<\/p>\n
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About G\u00e9nome Qu\u00e9bec<\/p>\n
Visit the Website<\/p>\n
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About Cancer Research UK<\/p>\n
Visit the Website<\/p>\n
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About CHU de Qu\u00e9bec<\/p>\n
Visit the Website<\/p>\n
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About COGS<\/p>\n
Visit the Website<\/p>\n
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About Dartmouth\u2019s Center for Genomic Medicine<\/p>\n
Visit the Website<\/p>\n
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About Harvard School of Public Health<\/p>\n
Visit the Website<\/p>\n
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About Institute of Cancer Research London UK Visit the Website<\/p>\n
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About Keck Medicine of USC<\/p>\n
Visit the Website<\/p>\n
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Moffit Cancer Center in Florida Visit the Website<\/p>\n
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About National Cancer Institute (USA)<\/p>\n
Visit the Web site<\/p>\n
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About Queensland institute of Medical Research Visit the Website<\/p>\n
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About Universit\u00e9 Laval<\/p>\n
Visit the Website<\/p>\n
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About University of Cambridge<\/p>\n
Visit the Website<\/p>\n
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\nFor more information:<\/p>\n
\u00c9va Kammer<\/p>\n
Director, Communications<\/p>\n
G\u00e9nome Qu\u00e9bec<\/p>\n
514 398-0668, ext. 206<\/p>\n
ekammer@genomequebec.com<\/p>\n","protected":false},"excerpt":{"rendered":"
Hundreds of researchers from North America, Europe, Australia and Asia have joined together in a consortium to identify the genetic basis of the five most common forms of cancer \u2013 breast, prostate, lung, ovarian and colorectal. The group, called the OncoArray Consortium, developed a new customized genotyping tool \u2013 the OncoArray \u2013 manufactured by the […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[127],"tags":[],"mission-categories":[],"class_list":["post-1516","post","type-post","status-publish","format-standard","hentry","category-news-fr"],"acf":[],"yoast_head":"\n