{"id":10473,"date":"2015-12-10T11:03:47","date_gmt":"2015-12-10T11:03:47","guid":{"rendered":"http:\/\/drupal.test\/projects\/reseau-de-montreal-de-pharmacoproteomique-et-de-genomique-structurelle\/"},"modified":"2022-07-29T16:08:48","modified_gmt":"2022-07-29T20:08:48","slug":"reseau-de-montreal-de-pharmacoproteomique-et-de-genomique-structurelle","status":"publish","type":"project","link":"https:\/\/genomecanada.ca\/fr\/project\/reseau-de-montreal-de-pharmacoproteomique-et-de-genomique-structurelle\/","title":{"rendered":"R\u00e9seau de Montr\u00e9al de pharmacoprot\u00e9omique et de g\u00e9nomique structurelle"},"content":{"rendered":"<p>Le Projet de g\u00e9nome humain a pour but principal d\u2019obtenir la s\u00e9quence compl\u00e8te de l\u2019ADN des humains et de nombreux autres organismes. L&rsquo;\u00e9tape suivante consiste \u00e0 d\u00e9terminer comment cette information g\u00e9n\u00e9tique oriente les r\u00e9actions biochimiques et mol\u00e9culaires dans les cellules et d\u00e9termine le fonctionnement des \u00eatres vivants. Ce type de recherche porte le nom de \u00ab g\u00e9nomique fonctionnelle \u00bb et vise \u00e0 d\u00e9couvrir comment les donn\u00e9es g\u00e9n\u00e9tiques cod\u00e9es dans l\u2019ADN guident tout le fonctionnement d\u2019un organisme vivant.<\/p>\n<p>L&rsquo;un des moyens utilis\u00e9s est l\u2019\u00e9tude des prot\u00e9ines dans une cellule \u2013 ce qu\u2019elles font, comment elles agissent les unes par rapport aux autres, et o\u00f9 elles se trouvent dans la cellule. C\u2019est ce qu\u2019on appelle la \u00ab prot\u00e9omique \u00bb et lorsqu\u2019on applique cette science \u00e0 la maladie, la\u00a0\u00ab pharmacoprot\u00e9omique \u00bb. La prot\u00e9omique a contribu\u00e9 \u00e0 la d\u00e9couverte des biomarqueurs qui peuvent indiquer la pr\u00e9sence d\u2019une maladie donn\u00e9e. Contrairement \u00e0 un g\u00e9nome, un prot\u00e9ome diff\u00e8re cependant d\u2019une cellule \u00e0 l\u2019autre et change constamment en raison d\u2019interactions biochimiques du g\u00e9nome et de l\u2019environnement. La cartographie des prot\u00e9ines humaines, de leurs fonctions et de leurs interactions s\u2019est av\u00e9r\u00e9e une t\u00e2che extr\u00eamement difficile pour les chercheurs. Pour ordonner le chaos de la prot\u00e9omique, nous avons d\u2019abord constitu\u00e9 une installation de calibre mondial qui permet aux chercheurs d\u2019\u00e9tudier la fonction et la structure des g\u00e8nes et des prot\u00e9ines qui pourraient utiles dans la mise au point de nouveaux m\u00e9dicaments. L\u2019installation, Caprion, repr\u00e9sente maintenant la norme internationale en cartographie, en identification et en caract\u00e9risation des prot\u00e9ines, et nos travaux ont men\u00e9 \u00e0 d\u2019importantes nouvelles d\u00e9couvertes et \u00e0 un changement du paradigme dans l\u2019\u00e9tude de la prot\u00e9omique. Cette installation est \u00e9galement le si\u00e8ge social de l\u2019International Human Proteome Organization (HUPO). Nous allions dans nos \u00e9tudes deux types de connaissances sp\u00e9cialis\u00e9es.<\/p>\n<p>Tout d\u2019abord, nous sommes sp\u00e9cialistes de l\u2019utilisation d\u2019une technologie appel\u00e9e spectrom\u00e9trie de masse, utilis\u00e9e pour d\u00e9terminer les nombreux types diff\u00e9rents de prot\u00e9ine qui existent dans la cellule. Deuxi\u00e8mement, nous sommes des experts de la purification et de l\u2019\u00e9tude de diff\u00e9rents types de machines miniatures qui effectuent des t\u00e2ches sp\u00e9cialis\u00e9es dans les cellules. Ces machines font penser \u00e0 des organes miniatures et c\u2019est pour cette raison qu\u2019on les appelle \u00ab organites \u00bb ou \u00ab organelles \u00bb. Nous combinons ces deux domaines en \u00e9tudiant la composition des prot\u00e9ines de certains types d\u2019organelles et mettons en corr\u00e9lation nos r\u00e9sultats avec le fonctionnement de la cellule et la maladie. Nous avons identifi\u00e9 la composition totale en prot\u00e9ines de plusieurs organelles.<\/p>\n<p>Compte tenu de la nature stochastique de la spectrom\u00e9trie de masse en tandem dans laquelle les prot\u00e9ines sont fragment\u00e9es, puis reconstitu\u00e9es par programmation informatique, nous avons a mis au point un microscope pour prot\u00e9ines. Dans ce cas, les prot\u00e9ines sont r\u00e9parties quantitativement dans diff\u00e9rents compartiments de la cellule par la prot\u00e9omique. Jusqu\u2019\u00e0 maintenant, nous avons visualis\u00e9 plus d\u2019une demi\u00addouzaine de ces organelles \u00e0 l\u2019aide du microscope pour prot\u00e9ines, ce qui nous permet de mieux comprendre l\u2019identit\u00e9 et la fonction de ces derni\u00e8res dans un organisme en sant\u00e9 et dans un organisme maladie. Nous avons d\u00e9pos\u00e9 ces donn\u00e9es dans une base de donn\u00e9es publique appel\u00e9e CellMap, qui a cr\u00e9\u00e9 une m\u00e9thode normalis\u00e9e de conception des exp\u00e9riences en prot\u00e9omique quantitative. Les cochercheurs ont \u00e9galement d\u00e9couvert et valid\u00e9 plus de prot\u00e9ines nouvelles li\u00e9es \u00e0 une structure particuli\u00e8re de la v\u00e9sicule que le reste du domaine combin\u00e9. Ils ont ainsi publi\u00e9 un grand nombre d\u2019articles dans des revues tr\u00e8s prestigieuses. Ce ne sont l\u00e0 que quelques faits saillants de nos principales d\u00e9couvertes.<\/p>\n<p>Dans le cadre de nos efforts de diffusion, le projet a \u00e9t\u00e9 d\u00e9crit dans Frontiers in Biotech 15, diffusion 12 d\u2019iPOD, intitul\u00e9 \u00ab The era of shock and awe in proteomics \u00bb par John Bergeron <a href=\"http:\/\/www.twit.tv\/fib\" target=\"_blank\" rel=\"noopener\"> http:\/\/www.twit.tv\/fib<\/a>.La valeur de notre travail a \u00e9t\u00e9 reconnue dans un \u00e9ditorial publi\u00e9 dans Nature (\u00ab Proteomics\u2019 new order \u00bb), qui a soulign\u00e9 l\u2019importance du si\u00e8ge social de HUPO \u00e0 Montr\u00e9al et son soutien dont il b\u00e9n\u00e9ficie du gouvernement canadien. Au bout du compte, cette recherche novatrice m\u00e8nera \u00e0 la d\u00e9couverte de nouveaux biomarqueurs, dont de nouvelles cibles pour le cancer et d\u2019autres maladies, offrant ainsi un avantage tangible \u00e0 la population canadienne et \u00e0 d\u2019autres.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Le Projet de g\u00e9nome humain a pour but principal d\u2019obtenir la s\u00e9quence compl\u00e8te de l\u2019ADN des humains et de nombreux autres organismes. L&rsquo;\u00e9tape suivante consiste \u00e0 d\u00e9terminer comment cette information g\u00e9n\u00e9tique oriente les r\u00e9actions biochimiques et mol\u00e9culaires dans les cellules et d\u00e9termine le fonctionnement des \u00eatres vivants. Ce type de recherche porte le nom de [&hellip;]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"project-categories":[93],"genome-competitions":[236],"project-sector":[],"genome_centres":[104],"class_list":["post-10473","project","type-project","status-publish","hentry","project-categories-large-scale-science-fr","genome-competitions-concours-i","genome_centres-genome-quebec-fr"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>R\u00e9seau de Montr\u00e9al de pharmacoprot\u00e9omique et de g\u00e9nomique structurelle - GenomeCanada<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/genomecanada.ca\/fr\/project\/reseau-de-montreal-de-pharmacoproteomique-et-de-genomique-structurelle\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"R\u00e9seau de Montr\u00e9al de pharmacoprot\u00e9omique et de g\u00e9nomique structurelle - GenomeCanada\" \/>\n<meta property=\"og:description\" content=\"Le Projet de g\u00e9nome humain a pour but principal d\u2019obtenir la s\u00e9quence compl\u00e8te de l\u2019ADN des humains et de nombreux autres organismes. 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