{"id":10480,"date":"2015-12-10T11:17:03","date_gmt":"2015-12-10T16:17:03","guid":{"rendered":"http:\/\/drupal.test\/projects\/biologie-integrative\/"},"modified":"2022-08-18T13:01:06","modified_gmt":"2022-08-18T17:01:06","slug":"biologie-integrative","status":"publish","type":"project","link":"https:\/\/genomecanada.ca\/fr\/project\/biologie-integrative\/","title":{"rendered":"Biologie\u00a0int\u00e9grative"},"content":{"rendered":"

R\u00e9sum\u00e9 du projet Les g\u00e9nomes de plus de 200 organismes ont \u00e9t\u00e9 s\u00e9quenc\u00e9s, depuis les vers de terre microscopiques aux humains. Les fonctions de milliers de g\u00e8nes retiennent l\u2019attention des chercheurs. La biologie int\u00e9grative r\u00e9v\u00e8le cependant que les g\u00e8nes ne fonctionnent pas individuellement, mais en regroupements physiques ou fonctionnels pour ex\u00e9cuter leurs fonctions.<\/p>\n

Mme<\/sup> Brenda Andrews est directrice du Terrence Donnelly Centre for Cellular and Biomolecular Research \u00e0 l\u2019Universit\u00e9 de Toronto, et directrice du projet Biologie int\u00e9grative. Selon Mme<\/sup> Andrews, les g\u00e8nes remplissent leurs fonctions non pas individuellement, mais collectivement ou en groupes. \u00c0 leur tour, ces groupes de g\u00e8nes interagissent pour permettre \u00e0 la cellule de fonctionner et de r\u00e9agir \u00e0 son environnement. La biologie int\u00e9grative r\u00e9v\u00e8le sa valeur dans le fait que certains m\u00e9dicaments sont hautement sp\u00e9cifiques et qu\u2019ils se lient \u00e0 une prot\u00e9ine et \u00e0 une prot\u00e9ine seulement. Ils peuvent n\u00e9anmoins avoir des effets impr\u00e9vus et ind\u00e9sirables lorsqu\u2019ils influencent des groupes de g\u00e8nes.<\/p>\n

Le projet dirig\u00e9 par Mme Andrews \u00e9laborera une vue int\u00e9gr\u00e9e de Saccharomyces cerevisiae (levure de boulanger) \u2013 un organisme mod\u00e8le important qui a conserv\u00e9 un grand nombre des m\u00eames g\u00e8nes et voies que les humains et qui se pr\u00eate bien \u00e0 l\u2019exp\u00e9rimentation. En examinant les cellules et les sous\u00ad\u00e9l\u00e9ments fonctionnels de la levure de boulanger, l\u2019\u00e9quipe du projet pr\u00e9voit obtenir des droits de propri\u00e9t\u00e9 intellectuelle pr\u00e9cieux. De nouveaux instruments, des r\u00e9actifs (substances utilis\u00e9es dans l\u2019analyse ou la synth\u00e8se chimiques), des m\u00e9thodologies pour des th\u00e9rapies humaines et v\u00e9t\u00e9rinaires, des r\u00e9actifs pour des fins industrielles et la recherche fondamentale et appliqu\u00e9e sont des exemples de propri\u00e9t\u00e9 intellectuelle.<\/p>\n

Situ\u00e9 au nouveau Terrence Donnelly Centre for Cellular and Biomolecular Research, le projet aidera \u00e0 cr\u00e9er une plate\u00adforme d\u2019avant-garde pour la g\u00e9nomique fonctionnelle et la prot\u00e9omique, et s\u2019appuiera sur des m\u00e9thodes multidisciplinaires et des ressources en recherche de Toronto et d\u2019ailleurs au Canada.<\/p>\n","protected":false},"excerpt":{"rendered":"

R\u00e9sum\u00e9 du projet Les g\u00e9nomes de plus de 200 organismes ont \u00e9t\u00e9 s\u00e9quenc\u00e9s, depuis les vers de terre microscopiques aux humains. Les fonctions de milliers de g\u00e8nes retiennent l\u2019attention des chercheurs. La biologie int\u00e9grative r\u00e9v\u00e8le cependant que les g\u00e8nes ne fonctionnent pas individuellement, mais en regroupements physiques ou fonctionnels pour ex\u00e9cuter leurs fonctions. Mme Brenda […]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"project-categories":[93],"genome-competitions":[238],"project-sector":[],"genome_centres":[108],"class_list":["post-10480","project","type-project","status-publish","hentry","project-categories-large-scale-science-fr","genome-competitions-concours-iii","genome_centres-ontario-genomics-fr"],"acf":[],"yoast_head":"\nBiologie\u00a0int\u00e9grative - GenomeCanada<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/genomecanada.ca\/fr\/project\/biologie-integrative\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Biologie\u00a0int\u00e9grative - GenomeCanada\" \/>\n<meta property=\"og:description\" content=\"R\u00e9sum\u00e9 du projet Les g\u00e9nomes de plus de 200 organismes ont \u00e9t\u00e9 s\u00e9quenc\u00e9s, depuis les vers de terre microscopiques aux humains. 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