{"id":10489,"date":"2015-12-10T11:28:09","date_gmt":"2015-12-10T11:28:09","guid":{"rendered":"http:\/\/drupal.test\/projects\/c-elegans-le-nematode-comme-organisme-modele\/"},"modified":"2022-07-29T16:13:20","modified_gmt":"2022-07-29T20:13:20","slug":"c-elegans-le-nematode-comme-organisme-modele","status":"publish","type":"project","link":"https:\/\/genomecanada.ca\/fr\/project\/c-elegans-le-nematode-comme-organisme-modele\/","title":{"rendered":"<i>C. elegans<\/i> : le n\u00e9matode comme organisme mod\u00e8le"},"content":{"rendered":"<p><i>C. elegans<\/i>, un minuscule ver rond qui a fait l\u2019objet de tr\u00e8s nombreuses \u00e9tudes pour mieux comprendre le fonctionnement d\u2019autres organismes, compte environ 7000 g\u00e8nes en commun avec le g\u00e9nome humain. Lorsqu\u2019ils sont dysfonctionnels chez les humains, ces g\u00e8nes peuvent mener \u00e0 des maladies h\u00e9r\u00e9ditaires, rendre vuln\u00e9rables \u00e0 des cancers et \u00e0 d\u2019autres probl\u00e8mes de sant\u00e9. La compr\u00e9hension de la fonction biologique fondamentale de <i>C. elegans<\/i> aura vraisemblablement des r\u00e9percussions directes sur les diagnostics et les traitements m\u00e9dicaux chez les humains.<\/p>\n<p>Au cours des quatre derni\u00e8res ann\u00e9es, notre \u00e9quipe internationale a identifi\u00e9 des mutations par d\u00e9l\u00e9tion dans plus de 2 000 g\u00e8nes. Avant ce projet, la communaut\u00e9 scientifique n&rsquo;avait identifi\u00e9, au cours des 25 derni\u00e8res ann\u00e9es, que 700 g\u00e8nes au moyen des mutations. Un certain nombre de g\u00e8nes cibl\u00e9s pour des souris knock-out sont analogues \u00e0 des g\u00e8nes pathologiques humains.<\/p>\n<p>Pour obtenir ces souris aux g\u00e8nes inactiv\u00e9s ou knock-out, l\u2019\u00e9quipe a mis en place une installation de calibre mondial qui fait partie d\u2019un consortium international de laboratoires dont l\u2019Oklahoma Medical Research Foundation et le Tokyo Women\u2019s Medical University School of Medicine \u2013 et a mis au point de nouvelles m\u00e9thodes novatrices. Notre protocole d\u2019inactivation est maintenant une norme dans de nombreux laboratoires dans le monde et notre r\u00e9cente innovation, les micropuces d\u2019hybridation g\u00e9nomique comparative (aCGG), pourrait r\u00e9volutionner la fa\u00e7on dont sont obtenues les souris knock-out et s\u2019av\u00e9rer indispensable dans les \u00e9tudes en biologie \u00e9volutionniste et en biologie des populations.<\/p>\n<p>\u00c0 mesure qu\u2019on conna\u00eetra mieux la biologie de ces g\u00e8nes, on pourra mettre au point de meilleurs outils de diagnostic et, \u00e0 terme, des produits th\u00e9rapeutiques. Un effet en aval digne de mention de ces travaux serait une meilleure sant\u00e9 et une meilleure qualit\u00e9 de vie dans les pays ravag\u00e9s par les n\u00e9matodoses (p. ex. la c\u00e9cit\u00e9 des rivi\u00e8res). La recherche sera \u00e9galement utile aux soci\u00e9t\u00e9s qui utilisent <i>C. elegans<\/i> pour d\u00e9couvrir des m\u00e9dicaments et comprendre les effets de ces derniers, en tant que test biologique peu co\u00fbteux de premier niveau, et pour d\u00e9pister les produits chimiques et mettre au point des n\u00e9maticides pour lutter contre les ravageurs en agriculture.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>C. elegans, un minuscule ver rond qui a fait l\u2019objet de tr\u00e8s nombreuses \u00e9tudes pour mieux comprendre le fonctionnement d\u2019autres organismes, compte environ 7000 g\u00e8nes en commun avec le g\u00e9nome humain. Lorsqu\u2019ils sont dysfonctionnels chez les humains, ces g\u00e8nes peuvent mener \u00e0 des maladies h\u00e9r\u00e9ditaires, rendre vuln\u00e9rables \u00e0 des cancers et \u00e0 d\u2019autres probl\u00e8mes de [&hellip;]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"project-categories":[93],"genome-competitions":[236],"project-sector":[],"genome_centres":[105],"class_list":["post-10489","project","type-project","status-publish","hentry","project-categories-large-scale-science-fr","genome-competitions-concours-i","genome_centres-genome-british-columbia-fr"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>C. elegans : le n\u00e9matode comme organisme mod\u00e8le - GenomeCanada<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/genomecanada.ca\/fr\/project\/c-elegans-le-nematode-comme-organisme-modele\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"C. elegans : le n\u00e9matode comme organisme mod\u00e8le - GenomeCanada\" \/>\n<meta property=\"og:description\" content=\"C. elegans, un minuscule ver rond qui a fait l\u2019objet de tr\u00e8s nombreuses \u00e9tudes pour mieux comprendre le fonctionnement d\u2019autres organismes, compte environ 7000 g\u00e8nes en commun avec le g\u00e9nome humain. Lorsqu\u2019ils sont dysfonctionnels chez les humains, ces g\u00e8nes peuvent mener \u00e0 des maladies h\u00e9r\u00e9ditaires, rendre vuln\u00e9rables \u00e0 des cancers et \u00e0 d\u2019autres probl\u00e8mes de [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/genomecanada.ca\/fr\/project\/c-elegans-le-nematode-comme-organisme-modele\/\" \/>\n<meta property=\"og:site_name\" content=\"GenomeCanada\" \/>\n<meta property=\"article:modified_time\" content=\"2022-07-29T20:13:20+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/project\\\/c-elegans-le-nematode-comme-organisme-modele\\\/\",\"url\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/project\\\/c-elegans-le-nematode-comme-organisme-modele\\\/\",\"name\":\"C. elegans : le n\u00e9matode comme organisme mod\u00e8le - GenomeCanada\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/#website\"},\"datePublished\":\"2015-12-10T11:28:09+00:00\",\"dateModified\":\"2022-07-29T20:13:20+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/project\\\/c-elegans-le-nematode-comme-organisme-modele\\\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/project\\\/c-elegans-le-nematode-comme-organisme-modele\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/project\\\/c-elegans-le-nematode-comme-organisme-modele\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"C. elegans : le n\u00e9matode comme organisme mod\u00e8le\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/#website\",\"url\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/\",\"name\":\"GenomeCanada\",\"description\":\"Harnessing the transformative power of genomics\",\"publisher\":{\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/#organization\",\"name\":\"GenomeCanada\",\"url\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/genomecanada.ca\\\/wp-content\\\/uploads\\\/2021\\\/07\\\/genome-canada_stacked.svg\",\"contentUrl\":\"https:\\\/\\\/genomecanada.ca\\\/wp-content\\\/uploads\\\/2021\\\/07\\\/genome-canada_stacked.svg\",\"width\":285,\"height\":180,\"caption\":\"GenomeCanada\"},\"image\":{\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"C. elegans : le n\u00e9matode comme organisme mod\u00e8le - GenomeCanada","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/genomecanada.ca\/fr\/project\/c-elegans-le-nematode-comme-organisme-modele\/","og_locale":"fr_FR","og_type":"article","og_title":"C. elegans : le n\u00e9matode comme organisme mod\u00e8le - GenomeCanada","og_description":"C. elegans, un minuscule ver rond qui a fait l\u2019objet de tr\u00e8s nombreuses \u00e9tudes pour mieux comprendre le fonctionnement d\u2019autres organismes, compte environ 7000 g\u00e8nes en commun avec le g\u00e9nome humain. 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