Au d\u00e9but de ce programme de recherche, en 2002, la communaut\u00e9 scientifique entrait dans l\u2019\u00e8re postg\u00e9nomique, arm\u00e9e d\u2019une foule de donn\u00e9es sur la s\u00e9quence du g\u00e9nome humain qui code l\u2019information n\u00e9cessaire \u00e0 la synth\u00e8se de l\u2019ARN et des prot\u00e9ines. On savait cependant peu de choses de l\u2019information r\u00e9gulatrice n\u00e9cessaire \u00e0 la sp\u00e9cification des ensembles de g\u00e8nes et de prot\u00e9ines exprim\u00e9s dans des conditions pr\u00e9cises pendant la croissance et le d\u00e9veloppement \u2013 non seulement le d\u00e9veloppement normal, mais aussi dans les processus responsables de maladies.<\/p>\n
Le programme visait principalement \u00e0 d\u00e9velopper et \u00e0 utiliser l\u2019expertise et les technologies pour d\u00e9couvrir le potentiel r\u00e9gulateur du g\u00e9nome humain, et \u00e0 \u00e9lucider les r\u00e9seaux d\u2019interaction prot\u00e9ines-ADN et prot\u00e9ines-prot\u00e9ines qui r\u00e9gulent la croissance et la diff\u00e9renciation des cellules. Notre approche unique nous a fait acqu\u00e9rir une mine de renseignements sur les r\u00e9seaux r\u00e9gulateurs impliqu\u00e9s dans la transcription des g\u00e8nes, dans le d\u00e9veloppement normal et les processus responsables de maladies telles que le cancer de la prostate et l’infection \u00e0 VIH.<\/p>\n
L\u2019\u00e9quipe a identifi\u00e9 de nombreuses nouvelles prot\u00e9ines et pr\u00e9voit poursuivre les exp\u00e9riences pour caract\u00e9riser leur r\u00f4le dans les processus responsables de maladies. Tout au long du projet, nous avons acquis d\u2019innombrables donn\u00e9es, du savoir faire et des outils dont des protocoles, des m\u00e9thodologies, des puces \u00e0 ADN, et des algorithmes et des bases de donn\u00e9es bioinformatiques. Nos puces \u00e0 ADN ont, en particulier, suscit\u00e9 beaucoup d\u2019int\u00e9r\u00eat dans la communaut\u00e9 scientifique et nous \u00e9valuons leur potentiel commercial. Nos d\u00e9couvertes et nos progr\u00e8s en science et en technologie ont consid\u00e9rablement enrichi le domaine de la r\u00e9gulation transcriptionnelle et ont acc\u00e9l\u00e9r\u00e9 la recherche en g\u00e9nomique, en prot\u00e9omique et en bioinformatique. On pr\u00e9voit que l\u2019identification de nouvelles cibles th\u00e9rapeutiques procurera des avantages sociaux et profitera, gr\u00e2ce \u00e0 la d\u00e9couverte de m\u00e9dicaments, au d\u00e9veloppement commercial et \u00e9conomique.<\/p>\n","protected":false},"excerpt":{"rendered":"
Au d\u00e9but de ce programme de recherche, en 2002, la communaut\u00e9 scientifique entrait dans l\u2019\u00e8re postg\u00e9nomique, arm\u00e9e d\u2019une foule de donn\u00e9es sur la s\u00e9quence du g\u00e9nome humain qui code l\u2019information n\u00e9cessaire \u00e0 la synth\u00e8se de l\u2019ARN et des prot\u00e9ines. On savait cependant peu de choses de l\u2019information r\u00e9gulatrice n\u00e9cessaire \u00e0 la sp\u00e9cification des ensembles de […]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"project-categories":[93],"genome-competitions":[237],"project-sector":[],"genome_centres":[104],"class_list":["post-10515","project","type-project","status-publish","hentry","project-categories-large-scale-science-fr","genome-competitions-concours-ii","genome_centres-genome-quebec-fr"],"acf":[],"yoast_head":"\n