Les infections fongiques, par exemple la candidose syst\u00e9mique et l\u2019aspergillose invasive, sont des causes principales de mortalit\u00e9 chez les patients immunod\u00e9prim\u00e9s. Au cours des derni\u00e8res d\u00e9cennies, la population \u00e0 risque dont font partie les patients atteints de sida, de cancer et les greff\u00e9s, a consid\u00e9rablement augment\u00e9.<\/p>\n
Malgr\u00e9 la pr\u00e9valence de ces infections fongiques virtuellement mort elles, les traitements sont restreints \u00e0 un petit nombre de m\u00e9dicaments antifongiques dont l\u2019utilisation est de plus en plus menac\u00e9e par l\u2019\u00e9mergence de champignons qui r\u00e9sistent aux m\u00e9dicaments et de graves probl\u00e8mes de toxicit\u00e9. Il est donc urgent de trouver une nouvelle g\u00e9n\u00e9ration de m\u00e9dicaments antifongiques dont l\u2019innocuit\u00e9 et l\u2019efficacit\u00e9 seront sup\u00e9rieures pour un spectre beaucoup plus grand de champignons.<\/p>\n
Notre projet visait g\u00e9n\u00e9ralement \u00e0 d\u00e9pister et \u00e0 identifier de nouvelles cibles de m\u00e9dicaments antifongiques bas\u00e9s sur la n\u00e9cessit\u00e9 d\u00e9montr\u00e9e de la croissance cellulaire. On a proc\u00e9d\u00e9 \u00e0 un d\u00e9pistage \u00e0 grande \u00e9chelle des g\u00e8nes essentiels dans Candida albicans<\/em> \u00e0 l\u2019aide d\u2019une strat\u00e9gie de construction de souches par remplacement et expression conditionnelle des g\u00e8nes (acronyme anglais GRACE) (Roemer et al., 2003). Nos efforts soutenus de validation des cibles nous ont permis d\u2019identifier plusieurs cibles antifongiques tr\u00e8s prometteuses, ainsi que des compos\u00e9s inhibiteurs correspondants (Rodriguez-Suarez et al., 2007; Jiang et al., 2008). Les compos\u00e9s antifongiques qui d\u00e9coulent de ce projet en sont actuellement \u00e0 divers stades de d\u00e9veloppement, allant du spectre des inhibiteurs en microbiologie et des \u00e9tudes des m\u00e9canismes d\u2019action \u00e0 l\u2019exploration en chimie m\u00e9dicinale. Les donn\u00e9es de validation des cibles procurent une information indispensable qui permet d\u2019\u00e9tablir des priorit\u00e9s parmi ces compos\u00e9s antifongiques en vue de leur d\u00e9veloppement \u00e9ventuel en aval. Des m\u00e9dicaments antifongiques plus s\u00fbrs et plus efficaces r\u00e9duiront les co\u00fbts des soins de sant\u00e9, tout en augmentant l\u2019esp\u00e9rance et la qualit\u00e9 de vie des patients. Notre \u00e9quipe s\u2019est attaqu\u00e9e au besoin d\u2019agents antifongiques d\u2019une mani\u00e8re et d\u2019une ampleur utiles pour la soci\u00e9t\u00e9 \u00e0 l\u2019\u00e9chelle internationale, et susceptibles d\u2019assurer des rendements \u00e9conomiques au Canada.<\/p>\n Nous avons continu\u00e9 \u00e0 progresser vers notre engagement \u00e0 publier des souches et diffuser des connaissances \u00e0 la communaut\u00e9 scientifique dans son ensemble. Gr\u00e2ce \u00e0 la diffusion des connaissances acquises et des technologies mises au point dans le cadre du projet, les chercheurs universitaires canadiens et \u00e9trangers disposeront de nouveaux outils et de nouvelles connaissances qui faciliteront la recherche scientifique fondamentale et feront grandir la notori\u00e9t\u00e9 internationale de la recherche en g\u00e9nomique de haute qualit\u00e9 men\u00e9e au Canada.<\/p>\n","protected":false},"excerpt":{"rendered":" Les infections fongiques, par exemple la candidose syst\u00e9mique et l\u2019aspergillose invasive, sont des causes principales de mortalit\u00e9 chez les patients immunod\u00e9prim\u00e9s. Au cours des derni\u00e8res d\u00e9cennies, la population \u00e0 risque dont font partie les patients atteints de sida, de cancer et les greff\u00e9s, a consid\u00e9rablement augment\u00e9. Malgr\u00e9 la pr\u00e9valence de ces infections fongiques virtuellement mort […]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"project-categories":[93],"genome-competitions":[237],"project-sector":[],"genome_centres":[104],"class_list":["post-10521","project","type-project","status-publish","hentry","project-categories-large-scale-science-fr","genome-competitions-concours-ii","genome_centres-genome-quebec-fr"],"acf":[],"yoast_head":"\n