{"id":10540,"date":"2015-12-10T12:40:43","date_gmt":"2015-12-10T17:40:43","guid":{"rendered":"http:\/\/drupal.test\/projects\/pathogenomique-fonctionnelle-de-limmunite-des-muqueuses\/"},"modified":"2022-08-17T13:40:19","modified_gmt":"2022-08-17T17:40:19","slug":"pathogenomique-fonctionnelle-de-limmunite-des-muqueuses","status":"publish","type":"project","link":"https:\/\/genomecanada.ca\/fr\/project\/pathogenomique-fonctionnelle-de-limmunite-des-muqueuses\/","title":{"rendered":"Pathog\u00e9nomique fonctionnelle de l\u2019immunit\u00e9 des muqueuses"},"content":{"rendered":"<p>La pathog\u00e9nomique est l\u2019\u00e9tude des g\u00e8nes h\u00f4tes humains ou animaux qui interviennent dans la r\u00e9action aux infections caus\u00e9es par des microbes comme les bact\u00e9ries et les virus. La premi\u00e8re \u00e9tape d\u2019une maladie infectieuse, commun\u00e9ment appel\u00e9e r\u00e9ponse immunitaire \u00ab inn\u00e9e \u00bb ou primaire, d\u00e9signe le contact des microbes avec les membranes muqueuses, dont les intestins, les voies respiratoires et l\u2019appareil urinaire. La compr\u00e9hension des g\u00e8nes qui participent aux interactions h\u00f4te-pathog\u00e8ne nous a permis de concevoir et de tester de nouvelles approches pour le traitement des infections.<\/p>\n<p>Nous avions pour objectif d\u2019utiliser les outils mis au point dans le cadre du Projet du g\u00e9nome humain tels que les puces \u00e0 ADN et l\u2019analyse computationnelle, pour \u00e9tudier les g\u00e8nes h\u00f4tes activ\u00e9s ou d\u00e9sactiv\u00e9s lorsque des cellules sont infect\u00e9es par des bact\u00e9ries ou des virus. Nous avons \u00e9galement \u00e9tudi\u00e9 l\u2019effet de compos\u00e9s appel\u00e9s peptides antimicrobiens et de vaccins sur la r\u00e9ponse immunitaire de l\u2019h\u00f4te, de m\u00eame que la capacit\u00e9 \u00e0 prot\u00e9ger contre les infections. Les th\u00e9rapies antibiotiques actuelles contre les maladies infectieuses ont fait augmenter le nombre d\u2019agents pathog\u00e8nes r\u00e9sistant aux antibiotiques, et il est urgent d\u2019adopter une nouvelle approche. Contrairement aux antibiotiques, les peptides antimicrobiens agissent sur la cellule h\u00f4te (humaine ou animale) et non sur le microbe, ce qui permet d\u2019\u00e9viter le probl\u00e8me de r\u00e9sistance aux antibiotiques.<\/p>\n<p>L\u2019un des points forts de notre \u00e9tude est l\u2019utilisation de cellules humaines et animales, de m\u00eame que de sp\u00e9cimens vivants comme des souris et des vaches. L\u2019utilisation de puces \u00e0 ADN nous a permis de d\u00e9terminer les g\u00e8nes importants dans la r\u00e9ponse immunitaire inn\u00e9e. Nous avons compar\u00e9 ces g\u00e8nes chez la souris, l\u2019humain et la vache. Nous avons d\u00e9pos\u00e9 plusieurs demandes de brevets pour les nouveaux peptides antimicrobiens qui semblent \u00e0 m\u00eame de stimuler la r\u00e9ponse immunitaire de l\u2019h\u00f4te sans entra\u00eener les effets n\u00e9fastes de l\u2019inflammation.<\/p>\n<p>Nous avons mis au point de nouvelles m\u00e9thodes d\u2019analyse computationnelle et les avons gratuitement mises \u00e0 la disposition de la communaut\u00e9 scientifique, notamment ArrayPipe, pour l\u2019analyse de r\u00e9seaux de g\u00e8nes, Ortholuge, pour la comparaison de g\u00e8nes semblables qui se retrouvent chez des esp\u00e8ces diff\u00e9rentes, et ProbeLynx, pour la mise \u00e0 jour automatique des donn\u00e9es sur des g\u00e8nes sp\u00e9cifiques utilis\u00e9s dans des r\u00e9seaux de g\u00e8nes.&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>La pathog\u00e9nomique est l\u2019\u00e9tude des g\u00e8nes h\u00f4tes humains ou animaux qui interviennent dans la r\u00e9action aux infections caus\u00e9es par des microbes comme les bact\u00e9ries et les virus. La premi\u00e8re \u00e9tape d\u2019une maladie infectieuse, commun\u00e9ment appel\u00e9e r\u00e9ponse immunitaire \u00ab inn\u00e9e \u00bb ou primaire, d\u00e9signe le contact des microbes avec les membranes muqueuses, dont les intestins, les [&hellip;]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"project-categories":[93],"genome-competitions":[237],"project-sector":[],"genome_centres":[107],"class_list":["post-10540","project","type-project","status-publish","hentry","project-categories-large-scale-science-fr","genome-competitions-concours-ii","genome_centres-genome-prairie-fr"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Pathog\u00e9nomique fonctionnelle de l\u2019immunit\u00e9 des muqueuses - GenomeCanada<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/genomecanada.ca\/fr\/project\/pathogenomique-fonctionnelle-de-limmunite-des-muqueuses\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Pathog\u00e9nomique fonctionnelle de l\u2019immunit\u00e9 des muqueuses - GenomeCanada\" \/>\n<meta property=\"og:description\" content=\"La pathog\u00e9nomique est l\u2019\u00e9tude des g\u00e8nes h\u00f4tes humains ou animaux qui interviennent dans la r\u00e9action aux infections caus\u00e9es par des microbes comme les bact\u00e9ries et les virus. 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