Pour que le d\u00e9veloppement se fasse normalement, l\u2019expression des g\u00e8nes doit \u00eatre soigneusement contr\u00f4l\u00e9e. De nombreux troubles tels que le cancer d\u00e9coulent d\u2019une r\u00e9gulation anormale des g\u00e8nes. Vu la facilit\u00e9 avec laquelle on peut \u00e9tudier la souris \u00e0 tous les stades de son d\u00e9veloppement, depuis le zygote unicellulaire jusqu\u2019\u00e0 l\u2019adulte, la souris est devenue un mod\u00e8le de premier choix en recherche biom\u00e9dicale pour l\u2019\u00e9tude du d\u00e9veloppement normal des mammif\u00e8res et des maladies humaines.<\/p>\n
Nous nous \u00e9tions fix\u00e9 comme objectif de cr\u00e9er un atlas des g\u00e8nes murins exprim\u00e9s tout au long du d\u00e9veloppement dans les nombreux tissus et au cours des diff\u00e9rents stades. Pour ce faire, nous avons mis au point des techniques de construction de biblioth\u00e8ques \u00e0 l\u2019aide de l\u2019\u00e9diteur SAGE et de s\u00e9quen\u00e7age qui n\u2019existent nulle part ailleurs dans le monde. Nous sommes remarquablement parvenus \u00e0 obtenir un d\u00e9bit rapide de s\u00e9quen\u00e7age, tout en maintenant la plus grande qualit\u00e9 possible des donn\u00e9es.<\/p>\n
Les chercheurs du projet ont construit une ressource concert\u00e9e \u00e0 grande \u00e9chelle \u2013 une collection de donn\u00e9es importantes que la plupart des laboratoires ne pourraient produire isol\u00e9ment. Cette ressource s\u2019av\u00e8re tr\u00e8s pr\u00e9cieuse pour les chercheurs qui analyseront les donn\u00e9es pendant de tr\u00e8s nombreuses ann\u00e9es.<\/p>\n
Les avantages possibles d\u00e9coulant de ce projet comprendront de meilleurs mod\u00e8les murins pour la recherche sur le cancer, le comportement et les troubles m\u00e9taboliques et au bout du compte, de meilleurs diagnostics et de meilleures cibles de m\u00e9dicaments que les soci\u00e9t\u00e9s pharmaceutiques pourront d\u00e9velopper. Il en r\u00e9sultera alors de nouveaux traitements du cancer, des troubles m\u00e9taboliques et des maladies g\u00e9n\u00e9tiques h\u00e9r\u00e9ditaires.<\/p>\n
<\/p>\n","protected":false},"excerpt":{"rendered":"
Pour que le d\u00e9veloppement se fasse normalement, l\u2019expression des g\u00e8nes doit \u00eatre soigneusement contr\u00f4l\u00e9e. De nombreux troubles tels que le cancer d\u00e9coulent d\u2019une r\u00e9gulation anormale des g\u00e8nes. Vu la facilit\u00e9 avec laquelle on peut \u00e9tudier la souris \u00e0 tous les stades de son d\u00e9veloppement, depuis le zygote unicellulaire jusqu\u2019\u00e0 l\u2019adulte, la souris est devenue un […]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"project-categories":[93],"genome-competitions":[237],"project-sector":[],"genome_centres":[105],"class_list":["post-10594","project","type-project","status-publish","hentry","project-categories-large-scale-science-fr","genome-competitions-concours-ii","genome_centres-genome-british-columbia-fr"],"acf":[],"yoast_head":"\n