{"id":10598,"date":"2015-12-10T14:49:33","date_gmt":"2015-12-10T19:49:33","guid":{"rendered":"http:\/\/drupal.test\/projects\/identification-efficace-et-clonage-des-suppressions-monogeniques-chez-le-nematode-caenorhabditis\/"},"modified":"2022-08-18T13:16:30","modified_gmt":"2022-08-18T17:16:30","slug":"identification-efficace-et-clonage-des-suppressions-monogeniques-chez-le-nematode-caenorhabditis","status":"publish","type":"project","link":"https:\/\/genomecanada.ca\/fr\/project\/identification-efficace-et-clonage-des-suppressions-monogeniques-chez-le-nematode-caenorhabditis\/","title":{"rendered":"Identification efficace et clonage des suppressions monog\u00e9niques chez le n\u00e9matode Caenorhabditis elegans<\/i>"},"content":{"rendered":"

Le n\u00e9matode (Caenorhabditis elegans<\/em>) est un petit ver d\u2019environ un millim\u00e8tre de long qui sert d\u2019organisme mod\u00e8le en recherche en g\u00e9n\u00e9tique. Son g\u00e9nome a \u00e9t\u00e9 le premier des m\u00e9tazoaires multicellulaires enti\u00e8rement s\u00e9quenc\u00e9 en 1998 et presque la moiti\u00e9 de ses g\u00e8nes ont des homologues chez les humains \u2013 des g\u00e8nes qui ont des fonctions comparables et des origines communes au fil de l\u2019\u00e9volution.<\/p>\n

M. Donald Moerman, professeur de zoologie \u00e0 l\u2019Universit\u00e9 de la Colombie-\u00adBritannique, est le directeur du projet Identification efficace et clonage des suppressions monog\u00e9niques chez le n\u00e9matode C. elegans.<\/em><\/p>\n

En collaboration avec le consortium international de neutralisation de g\u00e8nes du C. elegans,<\/em> M. Moerman mettra au point une ressource de souches mutantes du n\u00e9matode en supprimant ou en neutralisant des g\u00e8nes. Dans certains cas, l\u2019\u00e9quipe de recherche neutralisera des g\u00e8nes qui n\u2019appartiennent qu\u2019au n\u00e9matode. Ces g\u00e8nes peuvent \u00eatre importants du point de vue de la sant\u00e9 humaine et parce que les n\u00e9matodes constituent d\u2019importants parasites de l\u2019agriculture. Le ciblage de ces g\u00e8nes peut mener \u00e0 la mise au point de n\u00e9maticides particuliers.<\/p>\n

Dans d\u2019autres cas, l\u2019\u00e9quipe neutralisera des g\u00e8nes qui ont des homologues chez les humains. Un grand nombre des voies biochimiques sont les m\u00eames chez les n\u00e9matodes et les humains. Comme le n\u00e9matode est un organisme simple, il est souvent plus facile que chez les humains de d\u00e9terminer le r\u00f4le de g\u00e8nes sp\u00e9cifiques dans des voies biochimiques nouvelles ou existantes. Une meilleure compr\u00e9hension de la fonction biologique fondamentale des g\u00e8nes du n\u00e9matode pourrait avoir des r\u00e9percussions directes sur le diagnostic m\u00e9dical et le traitement de maladies h\u00e9r\u00e9ditaires chez les humains, par exemple le cancer.<\/p>\n

Le projet cr\u00e9era une ressource pr\u00e9cieuse pour la communaut\u00e9 internationale des chercheurs, car les n\u00e9matodes peuvent \u00eatre surgel\u00e9s, ce qui veut dire que les souches mutantes mises au point par l\u2019\u00e9quipe de recherche de M. Moerman pourront en permanence servir \u00e0 la communaut\u00e9 de recherche.<\/p>\n

(En anglais seulement)<\/p>\n

Integrated GE3<\/sup>LS Research:<\/strong> Assessing the use and impact of genomic resources released into the public domain
\nGE3<\/sup>LS Project Leaders: <\/strong>Lily Farris, University of British Columbia<\/p>\n

Summary<\/u><\/p>\n

The aim of this GE3<\/sup>LS project is to track the use of data and research materials produced by the C. elegans Gene Knockout Consortium (GKC) in order to understand how public domain information is accessed, used and incorporated into scientists\u2019 work.<\/p>\n

Researchers, funding bodies and society debate the benefits of moving scientific knowledge into the public domain as a means to maximize accessibility. By making basic research publically available, opportunities are created for new scientific innovation to be developed. We are working to provide examples of the uptake from the public domain by focusing on the use of one particular research project\u2019s body of publicly released data. By tracking the use of this openly available data source we are able to better understand how an open science system functions.  Using the C. elegans Gene Knockout Consortium (GKC) and the community of researchers who use C. elegans as a case study we are exploring how information is distributed through the  public domain by tracking the products (publications and patents) that arise from these freely released materials.   <\/p>\n

The C. elegans GKC was created in 2001 as a central large-scale production system used to generate C. elegans with knocked out or deleted genes creating the tools and worm strains with which other researchers can address specific basic biological and disease-related problems.The consortium is a prime example of public domain science in action as it shares all data and reagents with the public prior to publication. Genetic material, data and worms are made freely available to everyone, without restrictions from copyright, patents or other proprietary mechanisms.<\/p>\n

This GE3<\/sup>LS research project will explore the social and legal impact of the GKC and its practice of releasing data into the public domain. Members of the GE3<\/sup>LS team are analyzing how the GKC distributes worms (and their genetic data) in order to understand the downstream impact of this practice. Through the analysis of publications and patents which reference the use of C. elegans and the knockout consortium we aim to illustrate the process and exchange networks through which this upstream open science system functions.<\/p>\n","protected":false},"excerpt":{"rendered":"

Le n\u00e9matode (Caenorhabditis elegans) est un petit ver d\u2019environ un millim\u00e8tre de long qui sert d\u2019organisme mod\u00e8le en recherche en g\u00e9n\u00e9tique. Son g\u00e9nome a \u00e9t\u00e9 le premier des m\u00e9tazoaires multicellulaires enti\u00e8rement s\u00e9quenc\u00e9 en 1998 et presque la moiti\u00e9 de ses g\u00e8nes ont des homologues chez les humains \u2013 des g\u00e8nes qui ont des fonctions comparables […]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"project-categories":[93],"genome-competitions":[238],"project-sector":[],"genome_centres":[105],"class_list":["post-10598","project","type-project","status-publish","hentry","project-categories-large-scale-science-fr","genome-competitions-concours-iii","genome_centres-genome-british-columbia-fr"],"acf":[],"yoast_head":"\nIdentification efficace et clonage des suppressions monog\u00e9niques chez le n\u00e9matode Caenorhabditis elegans - GenomeCanada<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/genomecanada.ca\/fr\/project\/identification-efficace-et-clonage-des-suppressions-monogeniques-chez-le-nematode-caenorhabditis\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Identification efficace et clonage des suppressions monog\u00e9niques chez le n\u00e9matode Caenorhabditis elegans - GenomeCanada\" \/>\n<meta property=\"og:description\" content=\"Le n\u00e9matode (Caenorhabditis elegans) est un petit ver d\u2019environ un millim\u00e8tre de long qui sert d\u2019organisme mod\u00e8le en recherche en g\u00e9n\u00e9tique. 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