{"id":10636,"date":"2016-02-22T09:28:55","date_gmt":"2016-02-22T09:28:55","guid":{"rendered":"http:\/\/drupal.test\/projects\/outils-genomiques-de-diagnostic-et-devaluation-de-la-deficience-mentale\/"},"modified":"2022-07-27T08:46:53","modified_gmt":"2022-07-27T12:46:53","slug":"outils-genomiques-de-diagnostic-et-devaluation-de-la-deficience-mentale","status":"publish","type":"project","link":"https:\/\/genomecanada.ca\/fr\/project\/outils-genomiques-de-diagnostic-et-devaluation-de-la-deficience-mentale\/","title":{"rendered":"Outils g\u00e9nomiques de diagnostic et d\u2019\u00e9valuation de la d\u00e9ficience mentale"},"content":{"rendered":"

Am\u00e9liorer les diagnostics et l\u2019\u00e9valuation de la d\u00e9ficience mentale La d\u00e9ficience mentale est une incapacit\u00e9 \u00e0 vie qui touche plus de 300 000 Canadiennes et Canadiens. On ignore encore la cause de la plupart des manifestations de la d\u00e9ficience mentale, mais des anomalies chromosomiques comme le syndrome de Down sont souvent reconnues et \u00e9tudi\u00e9es. \u00ab\u00a0Depuis plus de 40 ans, nous avons utilis\u00e9 un proc\u00e9d\u00e9 appel\u00e9 caryotypage pour d\u00e9celer les anomalies chromosomiques,\u00a0\u00bb explique M. Jan Friedman de l\u2019Universit\u00e9 de la Colombie-Britannique. \u00ab\u00a0Malheureusement, le caryotypage est une technique de microscopie exigeante qui n\u00e9cessite une interpr\u00e9tation hautement sp\u00e9cialis\u00e9e. De plus, certains enfants atteints de d\u00e9ficience mentale ont des d\u00e9s\u00e9quilibres g\u00e9nomiques si petits que le caryotypage ne parvient pas \u00e0 les d\u00e9celer. Nous croyons toutefois que de nouveaux tests g\u00e9n\u00e9tiques nous permettront d\u2019identifier ces changements chromosomiques, en particulier les changements subtils, plus efficacement que le caryotypage.\u00a0\u00bb<\/p>\n

Dirig\u00e9 par MM. Jan Friedman et Marco Marra, le projet Outils g\u00e9nomiques de diagnostic et d\u2019\u00e9valuation de la d\u00e9ficience mentale a pour objet de trouver une solution de rechange au caryotypage pour identifier les anomalies chromosomiques chez les personnes atteintes de d\u00e9ficience mentale. L\u2019\u00e9quipe du projet \u00e9valuera une nouvelle m\u00e9thode d\u2019essai qui identifiera des anomalies chromosomiques 100 fois plus petites que les anomalies rep\u00e9rables par caryotypage.<\/p>\n

Le projet comprend la mise en \u0153uvre d\u2019une base de donn\u00e9es de recherches cliniques et cytog\u00e9n\u00e9tiques sp\u00e9cialis\u00e9es dans tous les centres participants afin de coordonner la collecte de donn\u00e9es cliniques et de sp\u00e9cimens. Un volet GE3<\/sup>DS portant sur les enjeux de la g\u00e9nomique li\u00e9s \u00e0 l\u2019\u00e9thique, \u00e0 l\u2019\u00e9conomie, \u00e0 l\u2019environnement, au droit et \u00e0 la soci\u00e9t\u00e9 garantira que l\u2019\u00e9change national des donn\u00e9es et des sp\u00e9cimens des recherches cliniques se fera dans un contexte juridique, \u00e9thique et social approuv\u00e9, qui refl\u00e9tera les normes canadiennes et internationales. Un volet d\u2019\u00e9valuation de la technologie sanitaire permettra d\u2019acqu\u00e9rir l\u2019expertise n\u00e9cessaire pour d\u00e9terminer si les patients, leur famille et le syst\u00e8me de sant\u00e9 canadien tireraient profit du remplacement du caryotypage courant par de nouvelles technologies d\u2019identification des anomalies chromosomiques chez les personnes atteintes de d\u00e9ficience mentale.<\/p>\n","protected":false},"excerpt":{"rendered":"

Am\u00e9liorer les diagnostics et l\u2019\u00e9valuation de la d\u00e9ficience mentale La d\u00e9ficience mentale est une incapacit\u00e9 \u00e0 vie qui touche plus de 300 000 Canadiennes et Canadiens. On ignore encore la cause de la plupart des manifestations de la d\u00e9ficience mentale, mais des anomalies chromosomiques comme le syndrome de Down sont souvent reconnues et \u00e9tudi\u00e9es. \u00ab\u00a0Depuis […]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"project-categories":[93],"genome-competitions":[231],"project-sector":[],"genome_centres":[105],"class_list":["post-10636","project","type-project","status-publish","hentry","project-categories-large-scale-science-fr","genome-competitions-recherche-en-genomique-et-en-proteomique-appliquee-a-la-sante-humaine","genome_centres-genome-british-columbia-fr"],"acf":[],"yoast_head":"\nOutils g\u00e9nomiques de diagnostic et d\u2019\u00e9valuation de la d\u00e9ficience mentale - GenomeCanada<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/genomecanada.ca\/fr\/project\/outils-genomiques-de-diagnostic-et-devaluation-de-la-deficience-mentale\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Outils g\u00e9nomiques de diagnostic et d\u2019\u00e9valuation de la d\u00e9ficience mentale - GenomeCanada\" \/>\n<meta property=\"og:description\" content=\"Am\u00e9liorer les diagnostics et l\u2019\u00e9valuation de la d\u00e9ficience mentale La d\u00e9ficience mentale est une incapacit\u00e9 \u00e0 vie qui touche plus de 300 000 Canadiennes et Canadiens. On ignore encore la cause de la plupart des manifestations de la d\u00e9ficience mentale, mais des anomalies chromosomiques comme le syndrome de Down sont souvent reconnues et \u00e9tudi\u00e9es. \u00ab\u00a0Depuis […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/genomecanada.ca\/fr\/project\/outils-genomiques-de-diagnostic-et-devaluation-de-la-deficience-mentale\/\" \/>\n<meta property=\"og:site_name\" content=\"GenomeCanada\" \/>\n<meta property=\"article:modified_time\" content=\"2022-07-27T12:46:53+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/project\\\/outils-genomiques-de-diagnostic-et-devaluation-de-la-deficience-mentale\\\/\",\"url\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/project\\\/outils-genomiques-de-diagnostic-et-devaluation-de-la-deficience-mentale\\\/\",\"name\":\"Outils g\u00e9nomiques de diagnostic et d\u2019\u00e9valuation de la d\u00e9ficience mentale - GenomeCanada\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/#website\"},\"datePublished\":\"2016-02-22T09:28:55+00:00\",\"dateModified\":\"2022-07-27T12:46:53+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/project\\\/outils-genomiques-de-diagnostic-et-devaluation-de-la-deficience-mentale\\\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/project\\\/outils-genomiques-de-diagnostic-et-devaluation-de-la-deficience-mentale\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/project\\\/outils-genomiques-de-diagnostic-et-devaluation-de-la-deficience-mentale\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Outils g\u00e9nomiques de diagnostic et d\u2019\u00e9valuation de la d\u00e9ficience mentale\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/#website\",\"url\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/\",\"name\":\"GenomeCanada\",\"description\":\"Harnessing the transformative power of genomics\",\"publisher\":{\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/#organization\",\"name\":\"GenomeCanada\",\"url\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/genomecanada.ca\\\/wp-content\\\/uploads\\\/2021\\\/07\\\/genome-canada_stacked.svg\",\"contentUrl\":\"https:\\\/\\\/genomecanada.ca\\\/wp-content\\\/uploads\\\/2021\\\/07\\\/genome-canada_stacked.svg\",\"width\":285,\"height\":180,\"caption\":\"GenomeCanada\"},\"image\":{\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Outils g\u00e9nomiques de diagnostic et d\u2019\u00e9valuation de la d\u00e9ficience mentale - GenomeCanada","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/genomecanada.ca\/fr\/project\/outils-genomiques-de-diagnostic-et-devaluation-de-la-deficience-mentale\/","og_locale":"fr_FR","og_type":"article","og_title":"Outils g\u00e9nomiques de diagnostic et d\u2019\u00e9valuation de la d\u00e9ficience mentale - GenomeCanada","og_description":"Am\u00e9liorer les diagnostics et l\u2019\u00e9valuation de la d\u00e9ficience mentale La d\u00e9ficience mentale est une incapacit\u00e9 \u00e0 vie qui touche plus de 300 000 Canadiennes et Canadiens. 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