{"id":10703,"date":"2016-09-19T16:25:40","date_gmt":"2016-09-19T16:25:40","guid":{"rendered":"http:\/\/drupal.test\/projects\/methodes-genematiques-et-bases-de-donnees-permettant-didentifier-les-petites-molecules-de-liaison\/"},"modified":"2022-07-29T15:54:02","modified_gmt":"2022-07-29T19:54:02","slug":"methodes-genematiques-et-bases-de-donnees-permettant-didentifier-les-petites-molecules-de-liaison","status":"publish","type":"project","link":"https:\/\/genomecanada.ca\/fr\/project\/methodes-genematiques-et-bases-de-donnees-permettant-didentifier-les-petites-molecules-de-liaison\/","title":{"rendered":"M\u00e9thodes g\u00e9n\u00e9matiques et bases de donn\u00e9es permettant d&rsquo;identifier les petites mol\u00e9cules de liaison \u00e0 l&rsquo;ARN qui r\u00e9gulent l&rsquo;expression g\u00e9n\u00e9tique"},"content":{"rendered":"<p>L&rsquo;ARN messager (ARNm) d\u00e9signe des mol\u00e9cules d&rsquo;ARN qui transportent les messages de l&rsquo;ADN dans le cadre de l&rsquo;expression g\u00e9n\u00e9tique. Les ribor\u00e9gulateurs, qui n&rsquo;ont \u00e9t\u00e9 d\u00e9couverts qu&rsquo;en 2002, semblent \u00eatre une classe ancienne, mais r\u00e9pandue, d&rsquo;\u00e9l\u00e9ments de l&rsquo;ARNm. L&rsquo;un de ces ribor\u00e9gulateurs, le ribor\u00e9gulateur activ\u00e9 par la flavine mononucl\u00e9otide (FMN), offre une cible prometteuse pour les antibiotiques. Ce ribor\u00e9gulateur joue un r\u00f4le essentiel dans la production de la riboflavine (ou vitamine\u00a0B<sub>2<\/sub>) chez les bact\u00e9ries, mais non chez les humains. L&rsquo;activation du ribor\u00e9gulateur FMN bact\u00e9rien pourrait donc interrompre cette voie biosynth\u00e9tique et emp\u00eacher la croissance des bact\u00e9ries, sans avoir d&rsquo;incidence sur la sant\u00e9 humaine. Il est tr\u00e8s probable que plusieurs autres ribor\u00e9gulateurs pourraient \u00eatre des cibles potentielles pour de nouvelles petites mol\u00e9cules th\u00e9rapeutiques. Il reste toutefois \u00e0 les d\u00e9couvrir, ainsi qu&rsquo;\u00e0 d\u00e9couvrir les petites mol\u00e9cules qui s&rsquo;y fixent.<\/p>\n<p>Cependant, la recherche de petites mol\u00e9cules peut \u00eatre un processus long et fastidieux. Le criblage virtuel \u00e0 haut d\u00e9bit est un proc\u00e9d\u00e9 \u00e0 la fois plus rapide et moins co\u00fbteux que toute autre approche exp\u00e9rimentale. Les professeurs J\u00e9r\u00f4me\u00a0Waldisp\u00fchl et Nicolas\u00a0Moitessier, tous deux de l&rsquo;Universit\u00e9 McGill, sont \u00e0 mettre au point l&rsquo;infrastructure et la technologie computationnelles n\u00e9cessaires pour le criblage du g\u00e9nome entier des \u00e9l\u00e9ments des ribor\u00e9gulateurs et pour l&rsquo;identification de petites mol\u00e9cules nouvelles qui les activent.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>L&rsquo;ARN messager (ARNm) d\u00e9signe des mol\u00e9cules d&rsquo;ARN qui transportent les messages de l&rsquo;ADN dans le cadre de l&rsquo;expression g\u00e9n\u00e9tique. Les ribor\u00e9gulateurs, qui n&rsquo;ont \u00e9t\u00e9 d\u00e9couverts qu&rsquo;en 2002, semblent \u00eatre une classe ancienne, mais r\u00e9pandue, d&rsquo;\u00e9l\u00e9ments de l&rsquo;ARNm. L&rsquo;un de ces ribor\u00e9gulateurs, le ribor\u00e9gulateur activ\u00e9 par la flavine mononucl\u00e9otide (FMN), offre une cible prometteuse pour les [&hellip;]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"project-categories":[94],"genome-competitions":[228],"project-sector":[],"genome_centres":[104],"class_list":["post-10703","project","type-project","status-publish","hentry","project-categories-leading-edge-technologies-fr","genome-competitions-concours-2015-en-bio-informatique-et-en-genematique","genome_centres-genome-quebec-fr"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>M\u00e9thodes g\u00e9n\u00e9matiques et bases de donn\u00e9es permettant d&#039;identifier les petites mol\u00e9cules de liaison \u00e0 l&#039;ARN qui r\u00e9gulent l&#039;expression g\u00e9n\u00e9tique - GenomeCanada<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/genomecanada.ca\/fr\/project\/methodes-genematiques-et-bases-de-donnees-permettant-didentifier-les-petites-molecules-de-liaison\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"M\u00e9thodes g\u00e9n\u00e9matiques et bases de donn\u00e9es permettant d&#039;identifier les petites mol\u00e9cules de liaison \u00e0 l&#039;ARN qui r\u00e9gulent l&#039;expression g\u00e9n\u00e9tique - GenomeCanada\" \/>\n<meta property=\"og:description\" content=\"L&rsquo;ARN messager (ARNm) d\u00e9signe des mol\u00e9cules d&rsquo;ARN qui transportent les messages de l&rsquo;ADN dans le cadre de l&rsquo;expression g\u00e9n\u00e9tique. Les ribor\u00e9gulateurs, qui n&rsquo;ont \u00e9t\u00e9 d\u00e9couverts qu&rsquo;en 2002, semblent \u00eatre une classe ancienne, mais r\u00e9pandue, d&rsquo;\u00e9l\u00e9ments de l&rsquo;ARNm. L&rsquo;un de ces ribor\u00e9gulateurs, le ribor\u00e9gulateur activ\u00e9 par la flavine mononucl\u00e9otide (FMN), offre une cible prometteuse pour les [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/genomecanada.ca\/fr\/project\/methodes-genematiques-et-bases-de-donnees-permettant-didentifier-les-petites-molecules-de-liaison\/\" \/>\n<meta property=\"og:site_name\" content=\"GenomeCanada\" \/>\n<meta property=\"article:modified_time\" content=\"2022-07-29T19:54:02+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/project\\\/methodes-genematiques-et-bases-de-donnees-permettant-didentifier-les-petites-molecules-de-liaison\\\/\",\"url\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/project\\\/methodes-genematiques-et-bases-de-donnees-permettant-didentifier-les-petites-molecules-de-liaison\\\/\",\"name\":\"M\u00e9thodes g\u00e9n\u00e9matiques et bases de donn\u00e9es permettant d'identifier les petites mol\u00e9cules de liaison \u00e0 l'ARN qui r\u00e9gulent l'expression g\u00e9n\u00e9tique - GenomeCanada\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/#website\"},\"datePublished\":\"2016-09-19T16:25:40+00:00\",\"dateModified\":\"2022-07-29T19:54:02+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/project\\\/methodes-genematiques-et-bases-de-donnees-permettant-didentifier-les-petites-molecules-de-liaison\\\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/project\\\/methodes-genematiques-et-bases-de-donnees-permettant-didentifier-les-petites-molecules-de-liaison\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/project\\\/methodes-genematiques-et-bases-de-donnees-permettant-didentifier-les-petites-molecules-de-liaison\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"M\u00e9thodes g\u00e9n\u00e9matiques et bases de donn\u00e9es permettant d&rsquo;identifier les petites mol\u00e9cules de liaison \u00e0 l&rsquo;ARN qui r\u00e9gulent l&rsquo;expression g\u00e9n\u00e9tique\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/#website\",\"url\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/\",\"name\":\"GenomeCanada\",\"description\":\"Harnessing the transformative power of genomics\",\"publisher\":{\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/#organization\",\"name\":\"GenomeCanada\",\"url\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/genomecanada.ca\\\/wp-content\\\/uploads\\\/2021\\\/07\\\/genome-canada_stacked.svg\",\"contentUrl\":\"https:\\\/\\\/genomecanada.ca\\\/wp-content\\\/uploads\\\/2021\\\/07\\\/genome-canada_stacked.svg\",\"width\":285,\"height\":180,\"caption\":\"GenomeCanada\"},\"image\":{\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"M\u00e9thodes g\u00e9n\u00e9matiques et bases de donn\u00e9es permettant d'identifier les petites mol\u00e9cules de liaison \u00e0 l'ARN qui r\u00e9gulent l'expression g\u00e9n\u00e9tique - GenomeCanada","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/genomecanada.ca\/fr\/project\/methodes-genematiques-et-bases-de-donnees-permettant-didentifier-les-petites-molecules-de-liaison\/","og_locale":"fr_FR","og_type":"article","og_title":"M\u00e9thodes g\u00e9n\u00e9matiques et bases de donn\u00e9es permettant d'identifier les petites mol\u00e9cules de liaison \u00e0 l'ARN qui r\u00e9gulent l'expression g\u00e9n\u00e9tique - GenomeCanada","og_description":"L&rsquo;ARN messager (ARNm) d\u00e9signe des mol\u00e9cules d&rsquo;ARN qui transportent les messages de l&rsquo;ADN dans le cadre de l&rsquo;expression g\u00e9n\u00e9tique. Les ribor\u00e9gulateurs, qui n&rsquo;ont \u00e9t\u00e9 d\u00e9couverts qu&rsquo;en 2002, semblent \u00eatre une classe ancienne, mais r\u00e9pandue, d&rsquo;\u00e9l\u00e9ments de l&rsquo;ARNm. L&rsquo;un de ces ribor\u00e9gulateurs, le ribor\u00e9gulateur activ\u00e9 par la flavine mononucl\u00e9otide (FMN), offre une cible prometteuse pour les [&hellip;]","og_url":"https:\/\/genomecanada.ca\/fr\/project\/methodes-genematiques-et-bases-de-donnees-permettant-didentifier-les-petites-molecules-de-liaison\/","og_site_name":"GenomeCanada","article_modified_time":"2022-07-29T19:54:02+00:00","twitter_card":"summary_large_image","twitter_misc":{"Dur\u00e9e de lecture estim\u00e9e":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/genomecanada.ca\/fr\/project\/methodes-genematiques-et-bases-de-donnees-permettant-didentifier-les-petites-molecules-de-liaison\/","url":"https:\/\/genomecanada.ca\/fr\/project\/methodes-genematiques-et-bases-de-donnees-permettant-didentifier-les-petites-molecules-de-liaison\/","name":"M\u00e9thodes g\u00e9n\u00e9matiques et bases de donn\u00e9es permettant d'identifier les petites mol\u00e9cules de liaison \u00e0 l'ARN qui r\u00e9gulent l'expression g\u00e9n\u00e9tique - GenomeCanada","isPartOf":{"@id":"https:\/\/genomecanada.ca\/fr\/#website"},"datePublished":"2016-09-19T16:25:40+00:00","dateModified":"2022-07-29T19:54:02+00:00","breadcrumb":{"@id":"https:\/\/genomecanada.ca\/fr\/project\/methodes-genematiques-et-bases-de-donnees-permettant-didentifier-les-petites-molecules-de-liaison\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/genomecanada.ca\/fr\/project\/methodes-genematiques-et-bases-de-donnees-permettant-didentifier-les-petites-molecules-de-liaison\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/genomecanada.ca\/fr\/project\/methodes-genematiques-et-bases-de-donnees-permettant-didentifier-les-petites-molecules-de-liaison\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/genomecanada.ca\/fr\/"},{"@type":"ListItem","position":2,"name":"M\u00e9thodes g\u00e9n\u00e9matiques et bases de donn\u00e9es permettant d&rsquo;identifier les petites mol\u00e9cules de liaison \u00e0 l&rsquo;ARN qui r\u00e9gulent l&rsquo;expression g\u00e9n\u00e9tique"}]},{"@type":"WebSite","@id":"https:\/\/genomecanada.ca\/fr\/#website","url":"https:\/\/genomecanada.ca\/fr\/","name":"GenomeCanada","description":"Harnessing the transformative power of genomics","publisher":{"@id":"https:\/\/genomecanada.ca\/fr\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/genomecanada.ca\/fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"},{"@type":"Organization","@id":"https:\/\/genomecanada.ca\/fr\/#organization","name":"GenomeCanada","url":"https:\/\/genomecanada.ca\/fr\/","logo":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/genomecanada.ca\/fr\/#\/schema\/logo\/image\/","url":"https:\/\/genomecanada.ca\/wp-content\/uploads\/2021\/07\/genome-canada_stacked.svg","contentUrl":"https:\/\/genomecanada.ca\/wp-content\/uploads\/2021\/07\/genome-canada_stacked.svg","width":285,"height":180,"caption":"GenomeCanada"},"image":{"@id":"https:\/\/genomecanada.ca\/fr\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/genomecanada.ca\/fr\/wp-json\/wp\/v2\/project\/10703","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/genomecanada.ca\/fr\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/genomecanada.ca\/fr\/wp-json\/wp\/v2\/types\/project"}],"version-history":[{"count":0,"href":"https:\/\/genomecanada.ca\/fr\/wp-json\/wp\/v2\/project\/10703\/revisions"}],"wp:attachment":[{"href":"https:\/\/genomecanada.ca\/fr\/wp-json\/wp\/v2\/media?parent=10703"}],"wp:term":[{"taxonomy":"project-categories","embeddable":true,"href":"https:\/\/genomecanada.ca\/fr\/wp-json\/wp\/v2\/project-categories?post=10703"},{"taxonomy":"genome-competitions","embeddable":true,"href":"https:\/\/genomecanada.ca\/fr\/wp-json\/wp\/v2\/genome-competitions?post=10703"},{"taxonomy":"project-sector","embeddable":true,"href":"https:\/\/genomecanada.ca\/fr\/wp-json\/wp\/v2\/project-sector?post=10703"},{"taxonomy":"genome_centres","embeddable":true,"href":"https:\/\/genomecanada.ca\/fr\/wp-json\/wp\/v2\/genome_centres?post=10703"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}