{"id":10758,"date":"2016-12-09T16:33:22","date_gmt":"2016-12-09T21:33:22","guid":{"rendered":"http:\/\/drupal.test\/projects\/analyse-multiomique-dexosomes-uniques\/"},"modified":"2023-06-02T14:16:52","modified_gmt":"2023-06-02T18:16:52","slug":"analyse-multiomique-dexosomes-uniques","status":"publish","type":"project","link":"https:\/\/genomecanada.ca\/fr\/project\/analyse-multiomique-dexosomes-uniques\/","title":{"rendered":"Analyse multiomique d\u2019exosomes uniques"},"content":{"rendered":"<p><strong>Projet de Phase 1<\/strong><\/p>\n<p>Les exosomes sont des nanov\u00e9sicules remplies de liquide (\u00ab\u00a0bulles\u00a0\u00bb) qui sont s\u00e9cr\u00e9t\u00e9es en grand nombre par les cellules canc\u00e9reuses et que l\u2019on peut extraire du sang. Les exosomes contiennent des mol\u00e9cules qui sont caract\u00e9ristiques de leurs cellules parentales; ils pourraient donc \u00eatre utilis\u00e9s pour identifier diff\u00e9rents types de cellules canc\u00e9reuses. Les tumeurs sont en effet tr\u00e8s h\u00e9t\u00e9rog\u00e8nes sur le plan de leur composition cellulaire et de l\u2019\u00e9tat de leurs cellules, et elles \u00e9voluent. Le nouveau d\u00e9fi en mati\u00e8re de traitement du cancer consiste \u00e0 suivre l\u2019h\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9 des tumeurs \u00e0 l\u2019aide d\u2019analyses de cellules uniques; de telles analyses n\u00e9cessitent toutefois du tissu tumoral et des biopsies. Comme on croit que les exosomes refl\u00e8tent l\u2019h\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9 des cellules tumorales, ils pourraient \u00eatre utilis\u00e9s comme marqueurs de substitution pour d\u00e9tecter l\u2019\u00e9mergence de clones tumoraux agressifs et r\u00e9sistants, et ce, par le simple pr\u00e9l\u00e8vement de quelques gouttes de sang. Les techniques d\u2019analyse actuelles des exosomes ne peuvent toutefois mesurer que les valeurs moyennes de populations d\u2019exosomes et ne permettent donc pas de discerner l\u2019h\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9 cellulaire exprim\u00e9e dans chaque exosome. Nous sommes de ce fait priv\u00e9s d\u2019information qui pourrait aider \u00e0 d\u00e9couvrir des facteurs cl\u00e9s dans la progression et la malignit\u00e9 des tumeurs.<\/p>\n<p>David\u00a0Juncker, Ph. D., et l\u2019\u00e9quipe de son laboratoire de l\u2019Universit\u00e9 McGill ont r\u00e9alis\u00e9 des avanc\u00e9es majeures dans le domaine de la nanotechnologie. Ils cherchent \u00e0 exploiter ces avanc\u00e9es pour mettre au point un outil r\u00e9volutionnaire d\u2019analyse des exosomes qui permettra d\u2019\u00e9tablir les profils des prot\u00e9ines et des acides nucl\u00e9iques contenus dans des millions d\u2019exosomes, \u00e0 un niveau de sensibilit\u00e9 monomol\u00e9culaire et \u00e0 une r\u00e9solution permettant de distinguer un exosome unique. Cette nouvelle technique d\u2019analyse ciblant des exosomes uniques pourrait r\u00e9volutionner le traitement du cancer en offrant un outil de diagnostic et de surveillance sensible. Les profils d\u2019exosomes uniques pr\u00e9lev\u00e9s du sang \u00e0 intervalles r\u00e9guliers (avant et apr\u00e8s la chirurgie) pourraient fournir des instantan\u00e9s en temps r\u00e9el de l\u2019h\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9 des tumeurs afin de suivre l\u2019\u00e9mergence de clones cellulaires agressifs et \u00eatre ult\u00e9rieurement utilis\u00e9s pour guider et personnaliser le traitement. La r\u00e9ussite de la recherche propos\u00e9e cr\u00e9erait un nouveau paradigme en mati\u00e8re de pratiques cliniques en faisant de la surveillance des exosomes un puissant outil venant s\u2019ajouter \u00e0 l\u2019arsenal dont on dispose d\u00e9j\u00e0 pour suivre la progression du cancer et en guider le traitement.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Projet de Phase 1 Les exosomes sont des nanov\u00e9sicules remplies de liquide (\u00ab\u00a0bulles\u00a0\u00bb) qui sont s\u00e9cr\u00e9t\u00e9es en grand nombre par les cellules canc\u00e9reuses et que l\u2019on peut extraire du sang. Les exosomes contiennent des mol\u00e9cules qui sont caract\u00e9ristiques de leurs cellules parentales; ils pourraient donc \u00eatre utilis\u00e9s pour identifier diff\u00e9rents types de cellules canc\u00e9reuses. Les [&hellip;]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"project-categories":[273,94],"genome-competitions":[217],"project-sector":[],"genome_centres":[104],"class_list":["post-10758","project","type-project","status-publish","hentry","project-categories-innovation-de-rupture","project-categories-leading-edge-technologies-fr","genome-competitions-concours-2015-innovation-de-rupture-en-genomique","genome_centres-genome-quebec-fr"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Analyse multiomique d\u2019exosomes uniques - GenomeCanada<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/genomecanada.ca\/fr\/project\/analyse-multiomique-dexosomes-uniques\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Analyse multiomique d\u2019exosomes uniques - GenomeCanada\" \/>\n<meta property=\"og:description\" content=\"Projet de Phase 1 Les exosomes sont des nanov\u00e9sicules remplies de liquide (\u00ab\u00a0bulles\u00a0\u00bb) qui sont s\u00e9cr\u00e9t\u00e9es en grand nombre par les cellules canc\u00e9reuses et que l\u2019on peut extraire du sang. Les exosomes contiennent des mol\u00e9cules qui sont caract\u00e9ristiques de leurs cellules parentales; ils pourraient donc \u00eatre utilis\u00e9s pour identifier diff\u00e9rents types de cellules canc\u00e9reuses. Les [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/genomecanada.ca\/fr\/project\/analyse-multiomique-dexosomes-uniques\/\" \/>\n<meta property=\"og:site_name\" content=\"GenomeCanada\" \/>\n<meta property=\"article:modified_time\" content=\"2023-06-02T18:16:52+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/project\\\/analyse-multiomique-dexosomes-uniques\\\/\",\"url\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/project\\\/analyse-multiomique-dexosomes-uniques\\\/\",\"name\":\"Analyse multiomique d\u2019exosomes uniques - GenomeCanada\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/#website\"},\"datePublished\":\"2016-12-09T21:33:22+00:00\",\"dateModified\":\"2023-06-02T18:16:52+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/project\\\/analyse-multiomique-dexosomes-uniques\\\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/project\\\/analyse-multiomique-dexosomes-uniques\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/project\\\/analyse-multiomique-dexosomes-uniques\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Analyse multiomique d\u2019exosomes uniques\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/#website\",\"url\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/\",\"name\":\"GenomeCanada\",\"description\":\"Harnessing the transformative power of genomics\",\"publisher\":{\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/#organization\",\"name\":\"GenomeCanada\",\"url\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/genomecanada.ca\\\/wp-content\\\/uploads\\\/2021\\\/07\\\/genome-canada_stacked.svg\",\"contentUrl\":\"https:\\\/\\\/genomecanada.ca\\\/wp-content\\\/uploads\\\/2021\\\/07\\\/genome-canada_stacked.svg\",\"width\":285,\"height\":180,\"caption\":\"GenomeCanada\"},\"image\":{\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Analyse multiomique d\u2019exosomes uniques - GenomeCanada","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/genomecanada.ca\/fr\/project\/analyse-multiomique-dexosomes-uniques\/","og_locale":"fr_FR","og_type":"article","og_title":"Analyse multiomique d\u2019exosomes uniques - GenomeCanada","og_description":"Projet de Phase 1 Les exosomes sont des nanov\u00e9sicules remplies de liquide (\u00ab\u00a0bulles\u00a0\u00bb) qui sont s\u00e9cr\u00e9t\u00e9es en grand nombre par les cellules canc\u00e9reuses et que l\u2019on peut extraire du sang. Les exosomes contiennent des mol\u00e9cules qui sont caract\u00e9ristiques de leurs cellules parentales; ils pourraient donc \u00eatre utilis\u00e9s pour identifier diff\u00e9rents types de cellules canc\u00e9reuses. Les [&hellip;]","og_url":"https:\/\/genomecanada.ca\/fr\/project\/analyse-multiomique-dexosomes-uniques\/","og_site_name":"GenomeCanada","article_modified_time":"2023-06-02T18:16:52+00:00","twitter_card":"summary_large_image","twitter_misc":{"Dur\u00e9e de lecture estim\u00e9e":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/genomecanada.ca\/fr\/project\/analyse-multiomique-dexosomes-uniques\/","url":"https:\/\/genomecanada.ca\/fr\/project\/analyse-multiomique-dexosomes-uniques\/","name":"Analyse multiomique d\u2019exosomes uniques - GenomeCanada","isPartOf":{"@id":"https:\/\/genomecanada.ca\/fr\/#website"},"datePublished":"2016-12-09T21:33:22+00:00","dateModified":"2023-06-02T18:16:52+00:00","breadcrumb":{"@id":"https:\/\/genomecanada.ca\/fr\/project\/analyse-multiomique-dexosomes-uniques\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/genomecanada.ca\/fr\/project\/analyse-multiomique-dexosomes-uniques\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/genomecanada.ca\/fr\/project\/analyse-multiomique-dexosomes-uniques\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/genomecanada.ca\/fr\/"},{"@type":"ListItem","position":2,"name":"Analyse multiomique d\u2019exosomes uniques"}]},{"@type":"WebSite","@id":"https:\/\/genomecanada.ca\/fr\/#website","url":"https:\/\/genomecanada.ca\/fr\/","name":"GenomeCanada","description":"Harnessing the transformative power of genomics","publisher":{"@id":"https:\/\/genomecanada.ca\/fr\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/genomecanada.ca\/fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"},{"@type":"Organization","@id":"https:\/\/genomecanada.ca\/fr\/#organization","name":"GenomeCanada","url":"https:\/\/genomecanada.ca\/fr\/","logo":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/genomecanada.ca\/fr\/#\/schema\/logo\/image\/","url":"https:\/\/genomecanada.ca\/wp-content\/uploads\/2021\/07\/genome-canada_stacked.svg","contentUrl":"https:\/\/genomecanada.ca\/wp-content\/uploads\/2021\/07\/genome-canada_stacked.svg","width":285,"height":180,"caption":"GenomeCanada"},"image":{"@id":"https:\/\/genomecanada.ca\/fr\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/genomecanada.ca\/fr\/wp-json\/wp\/v2\/project\/10758","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/genomecanada.ca\/fr\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/genomecanada.ca\/fr\/wp-json\/wp\/v2\/types\/project"}],"version-history":[{"count":0,"href":"https:\/\/genomecanada.ca\/fr\/wp-json\/wp\/v2\/project\/10758\/revisions"}],"wp:attachment":[{"href":"https:\/\/genomecanada.ca\/fr\/wp-json\/wp\/v2\/media?parent=10758"}],"wp:term":[{"taxonomy":"project-categories","embeddable":true,"href":"https:\/\/genomecanada.ca\/fr\/wp-json\/wp\/v2\/project-categories?post=10758"},{"taxonomy":"genome-competitions","embeddable":true,"href":"https:\/\/genomecanada.ca\/fr\/wp-json\/wp\/v2\/genome-competitions?post=10758"},{"taxonomy":"project-sector","embeddable":true,"href":"https:\/\/genomecanada.ca\/fr\/wp-json\/wp\/v2\/project-sector?post=10758"},{"taxonomy":"genome_centres","embeddable":true,"href":"https:\/\/genomecanada.ca\/fr\/wp-json\/wp\/v2\/genome_centres?post=10758"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}