{"id":10764,"date":"2016-12-09T16:53:19","date_gmt":"2016-12-09T21:53:19","guid":{"rendered":"http:\/\/drupal.test\/projects\/assemblage-pangenomique-de-novo-economique-et-haut-rendement\/"},"modified":"2023-06-02T14:16:13","modified_gmt":"2023-06-02T18:16:13","slug":"assemblage-pangenomique-de-novo-economique-et-haut-rendement","status":"publish","type":"project","link":"https:\/\/genomecanada.ca\/fr\/project\/assemblage-pangenomique-de-novo-economique-et-haut-rendement\/","title":{"rendered":"Assemblage pang\u00e9nomique de novo \u00e9conomique et \u00e0 haut rendement"},"content":{"rendered":"<p><strong>Projet de Phase 1<\/strong><\/p>\n<p>Le s\u00e9quen\u00e7age pang\u00e9nomique est une condition pr\u00e9alable de la m\u00e9decine de pr\u00e9cision ax\u00e9e sur les besoins particuliers d\u2019une personne dans son unicit\u00e9. La pratique courante, toutefois, est celle du \u00ab\u00a0res\u00e9quen\u00e7age\u00a0\u00bb qui consiste \u00e0 comparer le g\u00e9nome d\u2019une personne \u00e0 un g\u00e9nome de r\u00e9f\u00e9rence et \u00e0 prendre note des diff\u00e9rences. Cette fa\u00e7on de faire peut cependant passer \u00e0 c\u00f4t\u00e9 de la moiti\u00e9 presque des mutations \u00e0 la source de maladies. La solution de rechange \u2013 Le s\u00e9quen\u00e7age \u00ab\u00a0<em>de\u00a0novo<\/em>\u00a0\u00bb ou la construction du g\u00e9nome d\u2019une personne \u00e0 partir de ses propres donn\u00e9es seulement \u2013 est une t\u00e2che colossale qui s\u2019apparente \u00e0 l\u2019assemblage d\u2019un casse-t\u00eate compos\u00e9 de centaines de millions de petites pi\u00e8ces blanches dont seule la forme change. De plus, de nombreuses pi\u00e8ces pourraient avoir des formes identiques, correspondant \u00e0 des r\u00e9gions r\u00e9p\u00e9t\u00e9es du g\u00e9nome. En raison de ces particularit\u00e9s, les co\u00fbts financiers et logistiques du s\u00e9quen\u00e7age <em>de novo<\/em> sont peu pratiques, voire impossibles, dans l\u2019usage courant.<\/p>\n<p>Les Drs Si Lok, Stephen Scherer et leurs coll\u00e8gues de l\u2019H\u00f4pital pour enfants malades de Toronto d\u00e9veloppent une nouvelle technologie dite en \u00ab\u00a0mate pair\u00a0\u00bb, selon laquelle chaque lecture de s\u00e9quence est de toute \u00e9vidence reli\u00e9e \u00e0 une ou plusieurs autres lectures dans des orientations et \u00e0 des distances pr\u00e9cises connues. Dans l\u2019analogie du casse-t\u00eate, cette information permettrait de placer plusieurs morceaux par rapport aux autres sans devoir les toucher. Cette technologie cr\u00e9erait des interconnexions dans le g\u00e9nome pour donner une \u00ab\u00a0\u00e9pine dorsale\u00a0\u00bb de haute r\u00e9solution qui permettrait d\u2019effectuer le s\u00e9quen\u00e7age <em>de novo<\/em> en une seule \u00e9tape, ce qui \u00e9liminerait les obstacles \u00e0 la fois financiers et logistiques. Cette nouvelle adaptation du s\u00e9quen\u00e7age \u00ab\u00a0en mate pair\u00a0\u00bb est une technologie de rupture qui pourrait remplacer essentiellement toutes les m\u00e9thodes actuelles du s\u00e9quen\u00e7age <em>de novo<\/em>, ce qui repr\u00e9senterait une grande avanc\u00e9e dans la fa\u00e7on d\u2019utiliser la g\u00e9nomique dans de nombreux domaines de recherche, et un jour dans les soins de sant\u00e9.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Projet de Phase 1 Le s\u00e9quen\u00e7age pang\u00e9nomique est une condition pr\u00e9alable de la m\u00e9decine de pr\u00e9cision ax\u00e9e sur les besoins particuliers d\u2019une personne dans son unicit\u00e9. La pratique courante, toutefois, est celle du \u00ab\u00a0res\u00e9quen\u00e7age\u00a0\u00bb qui consiste \u00e0 comparer le g\u00e9nome d\u2019une personne \u00e0 un g\u00e9nome de r\u00e9f\u00e9rence et \u00e0 prendre note des diff\u00e9rences. Cette fa\u00e7on [&hellip;]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"project-categories":[273,94],"genome-competitions":[217],"project-sector":[],"genome_centres":[108],"class_list":["post-10764","project","type-project","status-publish","hentry","project-categories-innovation-de-rupture","project-categories-leading-edge-technologies-fr","genome-competitions-concours-2015-innovation-de-rupture-en-genomique","genome_centres-ontario-genomics-fr"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Assemblage pang\u00e9nomique de novo \u00e9conomique et \u00e0 haut rendement - GenomeCanada<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/genomecanada.ca\/fr\/project\/assemblage-pangenomique-de-novo-economique-et-haut-rendement\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Assemblage pang\u00e9nomique de novo \u00e9conomique et \u00e0 haut rendement - GenomeCanada\" \/>\n<meta property=\"og:description\" content=\"Projet de Phase 1 Le s\u00e9quen\u00e7age pang\u00e9nomique est une condition pr\u00e9alable de la m\u00e9decine de pr\u00e9cision ax\u00e9e sur les besoins particuliers d\u2019une personne dans son unicit\u00e9. La pratique courante, toutefois, est celle du \u00ab\u00a0res\u00e9quen\u00e7age\u00a0\u00bb qui consiste \u00e0 comparer le g\u00e9nome d\u2019une personne \u00e0 un g\u00e9nome de r\u00e9f\u00e9rence et \u00e0 prendre note des diff\u00e9rences. Cette fa\u00e7on [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/genomecanada.ca\/fr\/project\/assemblage-pangenomique-de-novo-economique-et-haut-rendement\/\" \/>\n<meta property=\"og:site_name\" content=\"GenomeCanada\" \/>\n<meta property=\"article:modified_time\" content=\"2023-06-02T18:16:13+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/project\\\/assemblage-pangenomique-de-novo-economique-et-haut-rendement\\\/\",\"url\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/project\\\/assemblage-pangenomique-de-novo-economique-et-haut-rendement\\\/\",\"name\":\"Assemblage pang\u00e9nomique de novo \u00e9conomique et \u00e0 haut rendement - GenomeCanada\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/#website\"},\"datePublished\":\"2016-12-09T21:53:19+00:00\",\"dateModified\":\"2023-06-02T18:16:13+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/project\\\/assemblage-pangenomique-de-novo-economique-et-haut-rendement\\\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/project\\\/assemblage-pangenomique-de-novo-economique-et-haut-rendement\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/project\\\/assemblage-pangenomique-de-novo-economique-et-haut-rendement\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Assemblage pang\u00e9nomique de novo \u00e9conomique et \u00e0 haut rendement\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/#website\",\"url\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/\",\"name\":\"GenomeCanada\",\"description\":\"Harnessing the transformative power of genomics\",\"publisher\":{\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/#organization\",\"name\":\"GenomeCanada\",\"url\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/genomecanada.ca\\\/wp-content\\\/uploads\\\/2021\\\/07\\\/genome-canada_stacked.svg\",\"contentUrl\":\"https:\\\/\\\/genomecanada.ca\\\/wp-content\\\/uploads\\\/2021\\\/07\\\/genome-canada_stacked.svg\",\"width\":285,\"height\":180,\"caption\":\"GenomeCanada\"},\"image\":{\"@id\":\"https:\\\/\\\/genomecanada.ca\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Assemblage pang\u00e9nomique de novo \u00e9conomique et \u00e0 haut rendement - GenomeCanada","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/genomecanada.ca\/fr\/project\/assemblage-pangenomique-de-novo-economique-et-haut-rendement\/","og_locale":"fr_FR","og_type":"article","og_title":"Assemblage pang\u00e9nomique de novo \u00e9conomique et \u00e0 haut rendement - GenomeCanada","og_description":"Projet de Phase 1 Le s\u00e9quen\u00e7age pang\u00e9nomique est une condition pr\u00e9alable de la m\u00e9decine de pr\u00e9cision ax\u00e9e sur les besoins particuliers d\u2019une personne dans son unicit\u00e9. La pratique courante, toutefois, est celle du \u00ab\u00a0res\u00e9quen\u00e7age\u00a0\u00bb qui consiste \u00e0 comparer le g\u00e9nome d\u2019une personne \u00e0 un g\u00e9nome de r\u00e9f\u00e9rence et \u00e0 prendre note des diff\u00e9rences. Cette fa\u00e7on [&hellip;]","og_url":"https:\/\/genomecanada.ca\/fr\/project\/assemblage-pangenomique-de-novo-economique-et-haut-rendement\/","og_site_name":"GenomeCanada","article_modified_time":"2023-06-02T18:16:13+00:00","twitter_card":"summary_large_image","twitter_misc":{"Dur\u00e9e de lecture estim\u00e9e":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/genomecanada.ca\/fr\/project\/assemblage-pangenomique-de-novo-economique-et-haut-rendement\/","url":"https:\/\/genomecanada.ca\/fr\/project\/assemblage-pangenomique-de-novo-economique-et-haut-rendement\/","name":"Assemblage pang\u00e9nomique de novo \u00e9conomique et \u00e0 haut rendement - GenomeCanada","isPartOf":{"@id":"https:\/\/genomecanada.ca\/fr\/#website"},"datePublished":"2016-12-09T21:53:19+00:00","dateModified":"2023-06-02T18:16:13+00:00","breadcrumb":{"@id":"https:\/\/genomecanada.ca\/fr\/project\/assemblage-pangenomique-de-novo-economique-et-haut-rendement\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/genomecanada.ca\/fr\/project\/assemblage-pangenomique-de-novo-economique-et-haut-rendement\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/genomecanada.ca\/fr\/project\/assemblage-pangenomique-de-novo-economique-et-haut-rendement\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/genomecanada.ca\/fr\/"},{"@type":"ListItem","position":2,"name":"Assemblage pang\u00e9nomique de novo \u00e9conomique et \u00e0 haut rendement"}]},{"@type":"WebSite","@id":"https:\/\/genomecanada.ca\/fr\/#website","url":"https:\/\/genomecanada.ca\/fr\/","name":"GenomeCanada","description":"Harnessing the transformative power of genomics","publisher":{"@id":"https:\/\/genomecanada.ca\/fr\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/genomecanada.ca\/fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"},{"@type":"Organization","@id":"https:\/\/genomecanada.ca\/fr\/#organization","name":"GenomeCanada","url":"https:\/\/genomecanada.ca\/fr\/","logo":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/genomecanada.ca\/fr\/#\/schema\/logo\/image\/","url":"https:\/\/genomecanada.ca\/wp-content\/uploads\/2021\/07\/genome-canada_stacked.svg","contentUrl":"https:\/\/genomecanada.ca\/wp-content\/uploads\/2021\/07\/genome-canada_stacked.svg","width":285,"height":180,"caption":"GenomeCanada"},"image":{"@id":"https:\/\/genomecanada.ca\/fr\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/genomecanada.ca\/fr\/wp-json\/wp\/v2\/project\/10764","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/genomecanada.ca\/fr\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/genomecanada.ca\/fr\/wp-json\/wp\/v2\/types\/project"}],"version-history":[{"count":0,"href":"https:\/\/genomecanada.ca\/fr\/wp-json\/wp\/v2\/project\/10764\/revisions"}],"wp:attachment":[{"href":"https:\/\/genomecanada.ca\/fr\/wp-json\/wp\/v2\/media?parent=10764"}],"wp:term":[{"taxonomy":"project-categories","embeddable":true,"href":"https:\/\/genomecanada.ca\/fr\/wp-json\/wp\/v2\/project-categories?post=10764"},{"taxonomy":"genome-competitions","embeddable":true,"href":"https:\/\/genomecanada.ca\/fr\/wp-json\/wp\/v2\/genome-competitions?post=10764"},{"taxonomy":"project-sector","embeddable":true,"href":"https:\/\/genomecanada.ca\/fr\/wp-json\/wp\/v2\/project-sector?post=10764"},{"taxonomy":"genome_centres","embeddable":true,"href":"https:\/\/genomecanada.ca\/fr\/wp-json\/wp\/v2\/genome_centres?post=10764"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}