{"id":10855,"date":"2018-01-26T20:08:21","date_gmt":"2018-01-26T20:08:21","guid":{"rendered":"http:\/\/drupal.test\/projects\/interrogation-et-utilisation-domiques-pour-un-traitement-de-precision-de-la-leucemie-myeloide-aigue\/"},"modified":"2022-07-26T11:09:27","modified_gmt":"2022-07-26T15:09:27","slug":"interrogation-et-utilisation-domiques-pour-un-traitement-de-precision-de-la-leucemie-myeloide-aigue","status":"publish","type":"project","link":"https:\/\/genomecanada.ca\/fr\/project\/interrogation-et-utilisation-domiques-pour-un-traitement-de-precision-de-la-leucemie-myeloide-aigue\/","title":{"rendered":"Interrogation et utilisation d\u2019omiques pour un traitement de pr\u00e9cision de la leuc\u00e9mie my\u00e9lo\u00efde aigu\u00eb"},"content":{"rendered":"<p>La leuc\u00e9mie my\u00e9lo\u00efde aigu\u00eb (LMA) est l\u2019une des premi\u00e8res causes de d\u00e9c\u00e8s li\u00e9 au cancer chez les jeunes adultes, et une maladie \u00e0 haut taux de mortalit\u00e9 chez les adultes plus \u00e2g\u00e9s. La plupart des patients ne survivent pas plus de deux ann\u00e9es apr\u00e8s le diagnostic de la LMA, en raison du manque d\u2019options de traitements efficaces et d\u2019outils mol\u00e9culaires inad\u00e9quats pour contr\u00f4ler le pronostic de la maladie. Le traitement des patients \u00e0 pronostic favorable (par chimioth\u00e9rapie) ou d\u00e9favorable (par greffe de cellules souches) est relativement simple. Ce sont les patients qui tombent entre ces deux cat\u00e9gories, les cas interm\u00e9diaires, qui posent le plus de probl\u00e8mes.<\/p>\n<p>En 2009, les chefs d\u2019\u00e9quipe de ce projet, Guy\u00a0Sauvageau de l\u2019Universit\u00e9 de Montr\u00e9al et Jos\u00e9e\u00a0H\u00e9bert de l\u2019H\u00f4pital Maisonneuve-Rosemont, ont lanc\u00e9 le projet Leuc\u00e9g\u00e8ne, aujourd\u2019hui chef de file international du d\u00e9chiffrement des anomalies g\u00e9n\u00e9tiques qui caract\u00e9risent la LMA. Les travaux de Leuc\u00e9g\u00e8ne ont men\u00e9 \u00e0 la mise en \u0153uvre imminente \u00e0 l\u2019\u00e9chelle mondiale d\u2019un nouveau test pronostique, qui permettra aux m\u00e9decins de pr\u00e9dire la r\u00e9ponse des patients aux th\u00e9rapies disponibles pour traiter la LMA. N\u00e9anmoins, les m\u00e9decins n\u2019arrivent pas \u00e0 d\u00e9terminer le traitement optimal de pas moins de 30\u00a0% des patients atteints de LMA.<\/p>\n<p>Ce projet a pour but de r\u00e9duire cette proportion \u00e0 moins de 10\u00a0% en appliquant de nouvelles technologies g\u00e9nomiques de pointe, qui devraient permettre de d\u00e9celer les variantes g\u00e9n\u00e9tiques jusqu&rsquo;ici inconnues et d\u2019\u00e9laborer de nouveaux tests pronostiques \u00e0 partir de cette information. L\u2019\u00e9quipe cherchera \u00e9galement des vuln\u00e9rabilit\u00e9s cl\u00e9s de la LMA que pourraient cibler des m\u00e9dicaments existants qui ne sont pas encore employ\u00e9s pour le traitement de la LMA, afin de d\u00e9terminer les th\u00e9rapies appropri\u00e9es pour davantage de patients.<\/p>\n<p>Les r\u00e9sultats de cette recherche seront publi\u00e9s sur un portail Web public pour appuyer les travaux d\u2019autres chercheurs et mettre l\u2019information \u00e0 la disposition des patients et des m\u00e9decins. L\u2019\u00e9quipe cr\u00e9era des lignes directrices strictes, en mati\u00e8re de d\u00e9ontologie et de droit, pour encadrer l\u2019usage du portail. Elle analysera \u00e9galement les co\u00fbts d\u00e9coulant des nouveaux tests, en les rapprochant des \u00e9conomies et des ann\u00e9es de productivit\u00e9 gagn\u00e9es par l\u2019application de meilleures strat\u00e9gies de traitement de la LMA.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>La leuc\u00e9mie my\u00e9lo\u00efde aigu\u00eb (LMA) est l\u2019une des premi\u00e8res causes de d\u00e9c\u00e8s li\u00e9 au cancer chez les jeunes adultes, et une maladie \u00e0 haut taux de mortalit\u00e9 chez les adultes plus \u00e2g\u00e9s. La plupart des patients ne survivent pas plus de deux ann\u00e9es apr\u00e8s le diagnostic de la LMA, en raison du manque d\u2019options de [&hellip;]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"project-categories":[93],"genome-competitions":[213],"project-sector":[],"genome_centres":[104],"class_list":["post-10855","project","type-project","status-publish","hentry","project-categories-large-scale-science-fr","genome-competitions-concours-2017-projets-de-recherche-appliquee-a-grande-echelle-la-genomique-et-la-sante-de-precision","genome_centres-genome-quebec-fr"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Interrogation et utilisation d\u2019omiques pour un traitement de pr\u00e9cision de la leuc\u00e9mie my\u00e9lo\u00efde aigu\u00eb - GenomeCanada<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/genomecanada.ca\/fr\/project\/interrogation-et-utilisation-domiques-pour-un-traitement-de-precision-de-la-leucemie-myeloide-aigue\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Interrogation et utilisation d\u2019omiques pour un traitement de pr\u00e9cision de la leuc\u00e9mie my\u00e9lo\u00efde aigu\u00eb - GenomeCanada\" \/>\n<meta property=\"og:description\" content=\"La leuc\u00e9mie my\u00e9lo\u00efde aigu\u00eb (LMA) est l\u2019une des premi\u00e8res causes de d\u00e9c\u00e8s li\u00e9 au cancer chez les jeunes adultes, et une maladie \u00e0 haut taux de mortalit\u00e9 chez les adultes plus \u00e2g\u00e9s. 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