L\u2019incidence des infections fongiques sur la sant\u00e9 humaine au Canada est profonde. De r\u00e9cents rapports \u00e9pid\u00e9miologiques font \u00e9tat d\u2019environ 3 000 infections fongiques envahissantes annuellement, responsables d\u2019environ 1 000 d\u00e9c\u00e8s. Les personnes qui pr\u00e9sentent une immunosuppression sont les plus vuln\u00e9rables. Seulement trois grandes cat\u00e9gories de m\u00e9dicaments antifongiques sont actuellement disponibles, et la r\u00e9sistance \u00e0 chacune de ces cat\u00e9gories augmente \u00e0 une vitesse alarmante. Cette \u00e9quipe a \u00e9tabli que les r\u00e9ponses au stress fongique \u00e9taient critiques pour la r\u00e9sistance aux m\u00e9dicaments antifongiques et les traits de virulence, et cern\u00e9 des inhibiteurs antifongiques du chaperon mol\u00e9culaire et du r\u00e9gulateur de la r\u00e9ponse au stress Hsp90. Ce projet allie l\u2019expertise en d\u00e9couverte informatique de m\u00e9dicaments de Schr\u00f6dinger \u00e0 l\u2019expertise du laboratoire de Cowen en mati\u00e8re de g\u00e9nomique fongique et de chaperon mol\u00e9culaire Hsp90, permettant \u00e0 Bright Angel Therapeutics de traduire rapidement les donn\u00e9es existantes qui appuient l\u2019argument voulant que le chaperon mol\u00e9culaire Hsp90 soit un candidat pr\u00eat \u00e0 faire l\u2019objet d\u2019une pr\u00e9sentation de drogue nouvelle de recherche. Le projet suivra une approche de mise au point en trois t\u00e2ches fond\u00e9e sur la conception informatique, le processus de chimie th\u00e9rapeutique cibl\u00e9e et la v\u00e9rification\/validation biologique. Le projet donne au Canada la possibilit\u00e9 de se positionner en tant que chef de file mondial en mati\u00e8re de recherche antifongique. Le m\u00e9dicament qui sera mis en march\u00e9 devrait r\u00e9duire la morbidit\u00e9 et la mortalit\u00e9 li\u00e9es aux infections fongiques et permettre des \u00e9conomies importantes au syst\u00e8me de soins de sant\u00e9 canadien, qui consacre actuellement 345 millions de dollars aux infections fongiques envahissantes.<\/p>\n","protected":false},"excerpt":{"rendered":"
L\u2019incidence des infections fongiques sur la sant\u00e9 humaine au Canada est profonde. De r\u00e9cents rapports \u00e9pid\u00e9miologiques font \u00e9tat d\u2019environ 3 000 infections fongiques envahissantes annuellement, responsables d\u2019environ 1 000 d\u00e9c\u00e8s. Les personnes qui pr\u00e9sentent une immunosuppression sont les plus vuln\u00e9rables. Seulement trois grandes cat\u00e9gories de m\u00e9dicaments antifongiques sont actuellement disponibles, et la r\u00e9sistance \u00e0 chacune […]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"project-categories":[92],"genome-competitions":[210],"project-sector":[],"genome_centres":[108],"class_list":["post-11017","project","type-project","status-publish","hentry","project-categories-translation-fr","genome-competitions-programme-de-partenariats-pour-les-applications-de-la-genomique","genome_centres-ontario-genomics-fr"],"acf":[],"yoast_head":"\n