Le cancer est responsable de 30\u00a0% de l\u2019ensemble des d\u00e9c\u00e8s au Canada. Au cours des deux\u00a0derni\u00e8res d\u00e9cennies, les maladies autrefois jug\u00e9es homog\u00e8nes d\u2019un tissu (par exemple, le cancer du sein) sont maintenant connues pour \u00eatre h\u00e9t\u00e9rog\u00e8nes, m\u00eame au sein de sous-types cliniques bien \u00e9tablis. Pour mieux comprendre la nature individuelle du cancer du sein chez les patientes, la mise en \u0153uvre de solutions \u00ab\u00a0omique\u00a0\u00bb int\u00e9gr\u00e9es est requise pour comprendre les effets combin\u00e9s des changements g\u00e9nomiques et \u00e9pig\u00e9nomiques dans la progression du cancer et tenir les promesses de la m\u00e9decine de pr\u00e9cision. Les nouvelles recherches sur le cancer du sein mettent en jeu l\u2019\u00e9pig\u00e9nomique dans la r\u00e9gulation de multiples processus canc\u00e9reux, notamment la r\u00e9paration de l\u2019ADN et la r\u00e9ponse au traitement. Les donn\u00e9es \u00e9pig\u00e9nomiques disponibles sur les g\u00e8nes moteurs du cancer de diff\u00e9rents groupes ethniques, en particulier des femmes d\u2019origine africaine, soulignent encore l\u2019importance des caract\u00e9ristiques \u00e9pig\u00e9nomiques sur le plan diagnostic dans les soins aux patients. Cela est essentiel pour fournir de soins de sant\u00e9 \u00e9quitables aux patientes, car une proportion importante de patientes peut ne pas \u00eatre trait\u00e9e de mani\u00e8re convenable en raison de processus mol\u00e9culaires influenc\u00e9s par les diff\u00e9rences li\u00e9es \u00e0 l\u2019ethnicit\u00e9. Le pr\u00e9sent projet permettra de d\u00e9velopper et de valider de nouvelles approches cibl\u00e9es fond\u00e9es sur des panels pour l\u2019\u00e9valuation des modifications \u00e9pig\u00e9n\u00e9tiques dans le cancer du sein, afin de r\u00e9pondre \u00e0 deux besoins importants\u00a0: l\u2019am\u00e9lioration des tests pr\u00e9dictifs et pronostiques pour toutes les patientes atteintes d\u2019un cancer du sein et une \u00e9tude cibl\u00e9e comparant les profils de m\u00e9thylation entre les cancers chez les minorit\u00e9s ethniques noires et asiatiques et chez d\u2019autres groupes ethniques.<\/p>\n","protected":false},"excerpt":{"rendered":"
Le cancer est responsable de 30\u00a0% de l\u2019ensemble des d\u00e9c\u00e8s au Canada. Au cours des deux\u00a0derni\u00e8res d\u00e9cennies, les maladies autrefois jug\u00e9es homog\u00e8nes d\u2019un tissu (par exemple, le cancer du sein) sont maintenant connues pour \u00eatre h\u00e9t\u00e9rog\u00e8nes, m\u00eame au sein de sous-types cliniques bien \u00e9tablis. Pour mieux comprendre la nature individuelle du cancer du sein chez […]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"project-categories":[92],"genome-competitions":[210],"project-sector":[],"genome_centres":[108],"class_list":["post-11104","project","type-project","status-publish","hentry","project-categories-translation-fr","genome-competitions-programme-de-partenariats-pour-les-applications-de-la-genomique","genome_centres-ontario-genomics-fr"],"acf":[],"yoast_head":"\n