Improving outcomes and increasing access for Canadian families-to-be
Around four million people use in vitro fertilization (IVF) every year, but only 34% of IVF cycles succeed. At least 85% of the time, the genetics of the embryo itself cause the high rate at which transferred embryos fail to implant or to carry to term. Despite its cost, roughly $20,000 per cycle, clinicians currently do not have the technology to perform comprehensive embryo genetic testing.
A new project, led by Jeremy Grushcow of Juniper Genomics and Dr. Sophie Petroloulos at the University of Montreal, aims to develop a comprehensive single-cell whole-genome sequencing-based genetic test for embryos to give IVF patients and clinicians as much certainty as possible that the first embryo they choose to transfer will be successful.
The project, called Whole genome embryo sequencing workflow for improved IVF outcomes, and run in partnership with Juniper Genomics, will deliver a scalable biopsy processing workflow for cell handling and sample preparation that delivers optimal sequencing results in a cost-effective manner. With close to $5.7 million, announced in May as part of a larger $41 million investment, the project has the potential to change transform IVF- improving outcomes and increasing access for Canadian patients.
ABOUT GAPP
The Genomic Applications Partnership Program (GAPP) supports industry-facing partnered research projects that address real-world challenges. Designed to accelerate the social and economic impact of genomics, GAPP provides the space for research, innovation and application to thrive collaboratively. GAPP projects address real-world challenges and opportunities through greater collaboration between genomics scientists and the users of genomics research. They aim to stimulate public- and private-sector investment in Canadian genomics technologies, advancing technology uptake in receptors and moving technologies across readiness levels.